Impaired hepatic removal of interleukin-6 in patients with liver cirrhosis

Cytokine
R WiestC Buechler

Abstract

Systemic concentrations of interleukin-6 (IL-6) are elevated in patients with liver cirrhosis, and impaired hepatic uptake of IL-6 was suggested to contribute to higher levels in these patients. To test this hypothesis IL-6 was measured in portal venous serum (PVS), hepatic venous serum (HVS) and systemic venous serum (SVS) of 41 patients with liver cirrhosis and four patients with normal liver function. IL-6 was higher in PVS than HVS of all blood donors and about 43% of portal vein derived IL-6 was extracted by the healthy liver, and 6.3% by the cirrhotic liver demonstrating markedly impaired removal of IL-6 by the latter. Whereas in patients with CHILD-PUGH stage A IL-6 in HVS was almost 25% lower than in PVS, in patients with CHILD-PUGH stage C IL-6 was similarly abundant in the two blood compartments. Ascites is a common complication in cirrhotic patients and was associated with higher IL-6 levels in all blood compartments without significant differences in hepatic excretion. Hepatic venous pressure gradient did not correlate with the degree of hepatic IL-6 removal excluding hepatic shunting as the principal cause of impaired IL-6 uptake. Furthermore, patients with alcoholic liver cirrhosis had higher IL-6 in all blood com...Continue Reading

Citations

Oct 29, 2011·Virology Journal·Quentin LepillerGeorges Herbein
Sep 3, 2013·Journal of Hepatology·Reiner WiestMarkus Geuking
Aug 16, 2011·Experimental and Molecular Pathology·Sabrina BauerChrista Buechler
Jul 17, 2013·European Journal of Clinical Investigation·Kristina EisingerChrista Buechler
Oct 9, 2015·Gastroenterology Research and Practice·Andrzej PrystupaWojciech Załuska
Nov 29, 2011·Molecular and Cellular Endocrinology·Josef WanningerChrista Buechler
Jan 18, 2015·Experimental and Molecular Pathology·Kristina EisingerChrista Buechler
Oct 6, 2016·Molecular and Cellular Endocrinology·Sabrina KrautbauerMarkus Neumeier
Jul 1, 2017·International Journal of Molecular Sciences·Christa BuechlerCharalampos Aslanidis
Dec 24, 2017·Scandinavian Journal of Clinical and Laboratory Investigation·Monika Gudowska-SawczukLech Chrostek
Aug 14, 2015·World Journal of Gastroenterology : WJG·Daniele SantettiHelena Ayako Sueno Goldani
Dec 1, 2020·Pharmacology & Therapeutics·Bingjian WenZhengquan Su
Jul 3, 2021·Journal of Clinical Medicine·Reiner WiestChrista Buechler

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