Impaired hippocampal-dependent memory and reduced parvalbumin-positive interneurons in a ketamine mouse model of schizophrenia

Schizophrenia Research
Ming Teng KohDani R Smith

Abstract

The hippocampus of patients with schizophrenia displays aberrant excess neuronal activity which affects cognitive function. Animal models of the illness have recapitulated the overactivity in the hippocampus, with a corresponding regionally localized reduction of inhibitory interneurons, consistent with that observed in patients. To better understand whether cognitive function is similarly affected in these models of hippocampal overactivity, we tested a ketamine mouse model of schizophrenia for cognitive performance in hippocampal- and medial prefrontal cortex (mPFC)-dependent tasks. We found that adult mice exposed to ketamine during adolescence were impaired on a trace fear conditioning protocol that relies on the integrity of the hippocampus. Conversely, the performance of the mice was normal on a delayed response task that is sensitive to mPFC damage. We confirmed that ketamine-exposed mice had reduced parvalbumin-positive interneurons in the hippocampus, specifically in the CA1, but not in the mPFC in keeping with the behavioral findings. These results strengthened the utility of the ketamine model for preclinical investigations of hippocampal overactivity in schizophrenia.

References

Nov 1, 1991·Archives of General Psychiatry·S HeckersH Beckmann
Mar 1, 1996·The American Journal of Psychiatry·M F Green
Aug 20, 1996·Proceedings of the National Academy of Sciences of the United States of America·M LaruelleR B Innis
Jul 18, 1997·Brain Research. Developmental Brain Research·S O Franklin
Jan 11, 2000·Journal of Psychiatric Research·J W OlneyN B Farber
Aug 16, 2000·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·B K Lipska, D R Weinberger
Dec 6, 2001·Hippocampus·D R MedoffC A Tamminga
May 3, 2002·The American Journal of Psychiatry·Mary A WalkerTimothy J Crow
Aug 23, 2002·Behavioural Brain Research·Mark Renato Stefani, Bita Moghaddam
Feb 13, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jason D RunyanPramod K Dash
Nov 9, 2004·Schizophrenia Research·Michael F GreenRobert K Heaton
Feb 5, 2005·Biological Psychiatry·E Fuller TorreyMichael B Knable
Nov 23, 2005·Behavioral Neuroscience·Najwa ChowdhuryMichael S Fanselow
May 1, 2007·Schizophrenia Research·A D EastvoldK S Cadenhead
May 5, 2007·Progress in Neuro-psychopharmacology & Biological Psychiatry·Jean-Philippe MarquisSonia Goulet
Oct 19, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Daniel J Lodge, Anthony A Grace
Sep 9, 2008·Acta Neuropathologica·Andrea SchmittPeter Falkai
Feb 27, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Daniel J LodgeAnthony A Grace
Mar 25, 2009·Progress in Neuro-psychopharmacology & Biological Psychiatry·Takeshi Enomoto, Stan B Floresco
Jan 13, 2010·Neuropsychology·Carol JahshanKristin S Cadenhead
Jan 21, 2010·Nature Reviews. Neuroscience·Peter J Uhlhaas, Wolf Singer
Apr 2, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jonathan L BrigmanAndrew Holmes
May 13, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Kathryn M GillAnthony A Grace
Jul 6, 2011·Neuropharmacology·Jared W YoungMark A Geyer
Jul 13, 2011·Schizophrenia Research·Christine KonradiStephan Heckers
Dec 31, 2011·Frontiers in Behavioral Neuroscience·Marta GuimarãisMarta A Moita
Apr 25, 2013·CNS Neuroscience & Therapeutics·Bernat KocsisMihaly Hajos
Jan 18, 2014·The American Journal of Psychiatry·Jason R TregellasRobert Freedman
May 3, 2014·The International Journal of Neuropsychopharmacology·Kathryn M Gill, Anthony A Grace
May 6, 2014·Proceedings of the National Academy of Sciences of the United States of America·Ahmed I GilaniHolly Moore

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Citations

May 16, 2019·The European Journal of Neuroscience·Victoria C OberlanderIleana L Hanganu-Opatz
Dec 3, 2016·Pharmacological Reports : PR·Joachim LatuszMarzena Maćkowiak
Sep 22, 2017·Translational Psychiatry·D A MaasG J M Martens
Feb 26, 2020·Journal of Molecular Neuroscience : MN·Runfang XieLinchuan Liao
Jul 30, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jacob B RudenChristine Konradi
Jul 14, 2017·Frontiers in Cellular Neuroscience·Malwina LisekTomasz Boczek

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