Impaired hippocampal synaptic plasticity and NR2A/2B expression ratio in remifentanil withdrawal rats

Neurotoxicology
Yi-Yi WangYinguo Zhang

Abstract

Remifentanil is a kind of synthetic opioid which has gained wide clinical acceptance by anesthesiologists. In this study, we attempted to test whether withdrawal effects on learning mechanisms can be triggered by repeated low-dose remifentanil treatment. Male Sprague-Dawley (SD) rats were subjected to remifentanil (50μg/kgs.c.) twice per day at 12h intervals for 15 days. When the animals of remifentanil group were withdrawn from remifentanil at 10h after the last injection, changes in open field test, Morris water maze test (MWM) and synaptic efficacy were examined in each group. We demonstrated that repeated exposure to 50μg/kg remifentanil produced enhanced locomotor activity indicating that a remifentanil addiction animal model in rats was established. MWM results showed that exposure to remifentanil had no influence on the spatial cognition. After withdrawal of remifentanil rats showed impaired spatial cognition. In electrophysiology test, remifentanil group rats showed a trend for a rightward shift of input/output relationship and significant deficits in maintenance of STP and LTP. Immunohistochemistry results demonstrated increased NR2A/NR2B ratio that should be included depression of LTP. In the whole-cell patch-clamp re...Continue Reading

References

Aug 1, 1990·The Journal of Pathology·A S Leong, J Milios
May 1, 1984·Journal of Neuroscience Methods·R Morris
Jun 24, 1982·Nature·R G MorrisJ O'Keefe
Mar 1, 1981·Pharmacology, Biochemistry, and Behavior·L S Brady, S G Holtzman
Oct 1, 1994·Journal of Analytical Toxicology·A J JenkinsE J Cone
Jun 1, 1994·Current Opinion in Neurobiology·M F Bear, R C Malenka
Feb 1, 1993·Clinical Neuropharmacology·G W Pasternak
Oct 6, 1997·Science·E J Nestler, G K Aghajanian
Oct 15, 1998·British Journal of Anaesthesia·D J Duthie
Jan 1, 1993·Behavioural Pharmacology·J. Stewart, A. Badiani
Mar 17, 2001·Nature Reviews. Neuroscience·E J Nestler
Jun 26, 2001·Science·E J Nestler
Feb 6, 2002·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·UNKNOWN American College of Critical Care Medicine of the Society of Critical Care Medicine, American Society of Health-System Pharm
Apr 23, 2003·Trends in Pharmacological Sciences·Solomon H Snyder, Gavril W Pasternak
Jan 17, 2004·Anaesthesia·G Basaranoglu
Jun 11, 2004·Annual Review of Biochemistry·Maria WaldhoerJennifer L Whistler
Sep 29, 2004·Neuron·Robert C Malenka, Mark F Bear
Oct 21, 2004·Science's STKE : Signal Transduction Knowledge Environment·Stuart G Cull-Candy, Daniel N Leszkiewicz
Dec 8, 2004·CNS Drugs·Richard Beers, Enrico Camporesi
Jan 26, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Guobin BaoGang Pei
Sep 6, 2007·Neuron·Camilla Bellone, Roger A Nicoll
Nov 10, 2007·Anaesthesia·R KomatsuC C Apfel
Mar 5, 2008·European Journal of Pharmacology·Lotfollah KhajehpourMohammad-Reza Zarrindast
Jun 24, 2008·Science & Practice Perspectives·Thomas R Kosten, Tony P George
Oct 8, 2008·Experimental and Clinical Psychopharmacology·Andrew RosenblumRussell K Portenoy
Jan 22, 2010·Pediatric Research·Xavier DurrmeyerPeter C Rimensberger
Oct 5, 2010·Neuron·Li-Min MaoJohn Q Wang

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