Impaired humoral and cellular immunity after SARS-CoV-2 BNT162b2 (tozinameran) prime-boost vaccination in kidney transplant recipients.

The Journal of Clinical Investigation
Arne SattlerK. Kotsch

Abstract

Novel mRNA-based vaccines have been proven to be powerful tools in combating the global pandemic caused by SARS-CoV-2, with BNT162b2 (trade name: Comirnaty) efficiently protecting individuals from COVID-19 across a broad age range. Still, it remains largely unknown how renal insufficiency and immunosuppressive medication affect development of vaccine-induced immunity. We therefore comprehensively analyzed humoral and cellular responses in kidney transplant recipients after the standard second vaccination dose. As opposed to all healthy vaccinees and the majority of hemodialysis patients, only 4 of 39 and 1 of 39 transplanted individuals showed IgA and IgG seroconversion at day 8 ± 1 after booster immunization, with minor changes until day 23 ± 5, respectively. Although most transplanted patients mounted spike-specific T helper cell responses, frequencies were significantly reduced compared with those in controls and dialysis patients and this was accompanied by a broad impairment in effector cytokine production, memory differentiation, and activation-related signatures. Spike-specific CD8+ T cell responses were less abundant than their CD4+ counterparts in healthy controls and hemodialysis patients and almost undetectable in tr...Continue Reading

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Citations

Jun 27, 2021·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·José Jesús BrosetaFrancisco Maduell
Aug 5, 2021·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Victoria G HallDeepali Kumar
Aug 3, 2021·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Kai-Ming ChangFrances R Wallach
Aug 25, 2021·Der Nephrologe·Elion Hoxha
Aug 29, 2021·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Tina SchmidtJanine Mihm
Jun 8, 2021·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Meaghan M Phipps, Elizabeth C Verna
Aug 28, 2021·Transplant International : Official Journal of the European Society for Organ Transplantation·Maddalena GiannellaOriol Manuel
Jul 22, 2021·Transplant International : Official Journal of the European Society for Organ Transplantation·Refik GökmenFrank J M F Dor
Sep 30, 2021·Bone Marrow Transplantation·Anne-Claire MamezYves Chalandon
Oct 7, 2021·Der Internist·Anahita Fathi, Sibylle C Mellinghoff
Oct 21, 2021·Journal of the American Society of Nephrology : JASN·Eva SchrezenmeierFabian Halleck

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Datasets Mentioned

BETA
MN908947.3

Methods Mentioned

BETA
ELISA
PCR
RNA-Seq
FACS
density gradient centrifugation

Software Mentioned

FlowJo
STAR
ENSEMBL
Gene Set Enrichment Analysis ( GSEA
R
DESeq2
GraphPad Prism
Cytobank

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