PMID: 8964193Feb 1, 1996Paper

Impaired hyperemic response of brachial artery with the presence of diabetes mellitus in patients with coronary artery disease: a preliminary study

Diabetes Research and Clinical Practice
H TomoikeI Kubota

Abstract

Microvascular reactivity was assessed in reactive hyperemic response of brachial artery in 10 patients with non-insulin-dependent diabetes mellitus and 34 non-diabetic patients. Each subject was diagnosed clinically as having angina pectoris and was examined by coronary angiography. Brachial arterial flow was determined by a pulsed Doppler velocity measurement, guided by a high-resolution B-mode imaging of the forearm. Peak systolic velocity at the basal state in diabetic and non-diabetic patients was comparable (0.53 +/- 0.03 versus 0.61 +/- 0.04 m/s, respectively; P = NS). The velocity ratio of the peak systolic flow at the basal state to the maximum velocity during hyperemia of 2 min arterial occlusion tended to be less in diabetic than in non-diabetic patients (1.76 +/- 0.14 versus 2.15 +/- 0.13, respectively; P = NS). The duration of hyperemic flow was less in diabetic than in non-diabetic patients (6.7 +/- 0.7 versus 9.9 +/- 0.6 s, respectively; P < 0.02). Such alterations in reactive hyperemia may be relevant to the microvascular disorder of the peripheral vessel in the presence of diabetes mellitus.

Citations

Apr 3, 2012·The Journal of Orthopaedic and Sports Physical Therapy·Jaap J J BrunnekreefMaria T E Hopman
Dec 13, 2002·The New England Journal of Medicine·Kerry J StewartAlan T Hirsch

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