Impaired hypocretin/orexin system alters responses to salient stimuli in obese male mice.

The Journal of Clinical Investigation
Ying TanXiao-Bing Gao

Abstract

The brain has evolved in an environment where food sources are scarce, and foraging for food is one of the major challenges for survival of the individual and species. Basic and clinical studies show that obesity or overnutrition leads to overwhelming changes in the brain in animals and humans. However, the exact mechanisms underlying the consequences of excessive energy intake are not well understood. Neurons expressing the neuropeptide hypocretin/orexin (Hcrt) in the lateral/perifonical hypothalamus (LH) are critical for homeostatic regulation, reward seeking, stress response, and cognitive functions. In this study, we examined adaptations in Hcrt cells regulating behavioral responses to salient stimuli in diet-induced obese mice. Our results demonstrated changes in primary cilia, synaptic transmission and plasticity, cellular responses to neurotransmitters necessary for reward seeking, and stress responses in Hcrt neurons from obese mice. Activities of neuronal networks in the LH and hippocampus were impaired as a result of decreased hypocretinergic function. The weakened Hcrt system decreased reward seeking while altering responses to acute stress (stress-coping strategy), which were reversed by selectively activating Hcrt ...Continue Reading

References

Feb 21, 1998·Proceedings of the National Academy of Sciences of the United States of America·L de LeceaJ G Sutcliffe
Jun 30, 1998·Archives of Internal Medicine·A N VgontzasA Kales
Nov 20, 1998·FEBS Letters·P TrivediX M Guan
Jan 20, 1999·Proceedings of the National Academy of Sciences of the United States of America·Y DateM Nakazato
Jan 1, 2000·Lancet·S NishinoE Mignot
Oct 31, 2000·Neuron·T C ThannickalJ M Siegel
May 23, 2001·The Journal of Comparative Neurology·J N MarcusJ K Elmquist
Aug 21, 2001·Biochemical and Biophysical Research Communications·B BeckA Stricker-Krongrad
Feb 1, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Katherine E WortleySarah F Leibowitz
May 7, 2003·Proceedings of the National Academy of Sciences of the United States of America·Malika El YacoubiJean-Marie Vaugeois
Jun 1, 2005·Neuron·Boris Y MileykovskiyJerome M Siegel
Jun 28, 2005·The European Journal of Neuroscience·Michael BubserAriel Y Deutch
Jul 15, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Maan Gee LeeBarbara E Jones
Aug 16, 2005·Nature·Glenda C HarrisGary Aston-Jones
Dec 17, 2005·Proceedings of the National Academy of Sciences of the United States of America·Benjamin BoutrelLuis de Lecea
Sep 28, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Masato FukuiWilliam C Wetsel
Dec 7, 2007·The Journal of Clinical Investigation·Yan RaoXiao-Bing Gao
Sep 12, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yan RaoXiao-Bing Gao
Apr 10, 2009·Journal of Neurophysiology·Matthew R CampioniDaniel S McGehee
Nov 26, 2009·Proceedings of the National Academy of Sciences of the United States of America·Adriano B L TortHoward Eichenbaum
Jun 18, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Matthew P Parsons, Michiru Hirasawa
Aug 3, 2010·Proceedings of the National Academy of Sciences of the United States of America·David M LyonsAlan F Schatzberg
Oct 13, 2011·Nature Reviews. Neuroscience·Alfred J Robison, Eric J Nestler
Oct 21, 2011·Nature Reviews. Neuroscience·Paul J Kenny
Feb 7, 2012·Nature Neuroscience·Natsuko KumamotoShaoyu Ge
Apr 18, 2012·International Journal of Obesity : Journal of the International Association for the Study of Obesity·S Sharma, S Fulton
May 30, 2012·The Journal of Physiology·Jiann Wei YeohChristopher V Dayas
Jun 26, 2012·Nature Neuroscience·Marcelo O DietrichTamas L Horvath
Jul 21, 2012·Progress in Brain Research·Andrea R Di Sebastiano, Lique M Coolen
Mar 15, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Monica S Thanawala, Wade G Regehr

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