PMID: 9558010Apr 29, 1998Paper

Impaired hypothalamus-pituitary-adrenal axis in men with spinal cord injuries

American Journal of Physical Medicine & Rehabilitation
T S HuangJ S Lai

Abstract

Twenty-five men with spinal cord injuries were studied for evaluation of the hypothalamus-pituitary-adrenal axis, using corticotropin-releasing hormone and insulin-induced hypoglycemia. Twenty-five age-matched healthy male volunteers served as controls. Three spinal cord-injured subjects had hyperprolactinemia, three had elevated basal follicle-stimulating hormone levels, one had an elevated basal luteinizing hormone level, and four had hypotestosteronemia. The mean plasma adrenocorticotropin response to corticotropin-releasing hormone of spinal cord-injured subjects was smaller than that of the healthy controls but did not reach a statistical significance. The cortisol response to corticotropin-releasing hormone of the spinal cord-injured subjects was significantly lower than that of healthy controls. However, the difference disappeared if a correction was made for baseline values. Six spinal cord-injured subjects did not have a cortisol response to insulin-induced hypoglycemia, and they had either a minimal or no adrenocorticotropin response. Another 11 spinal cord-injured subjects had a maximal cortisol response to insulin-induced hypoglycemia below the lowest limit of normal, i.e., 0.5 micromol/l. Among these spinal cord-in...Continue Reading

References

May 1, 1988·Muscle & Nerve·R W KunclJ W Griffin
Jan 1, 1983·Spine·A Eisen, M Hoirch
May 1, 1993·Archives of Physical Medicine and Rehabilitation·J SteinZ M Pine
May 1, 1996·Muscle & Nerve·T D Lauder, T R Dillingham

❮ Previous
Next ❯

Citations

Sep 7, 2007·Neurocritical Care·Kyle A WeantEldad J Hadar
Jan 26, 2000·Critical Care Nursing Quarterly·J Sullivan
Nov 29, 2011·World Neurosurgery·Emil A PastranaGloria Rodriguez-Vega
Oct 26, 2011·PM & R : the Journal of Injury, Function, and Rehabilitation·Anita DurgaDeborah A Crane
Mar 14, 2014·The Journal of Spinal Cord Medicine·Lei WangJishan Yuan
Jun 28, 2014·The Journal of Spinal Cord Medicine·Huiqing YangJeffrey Harrow
Jun 17, 2000·Archives of Physical Medicine and Rehabilitation·L W Lee, M B Glenn
Mar 20, 2002·Mechanisms of Development·Yuko TadokoroYoshitake Nishimune
Aug 24, 1999·Archives of Physical Medicine and Rehabilitation·Y H Wang, T S Huang
Jun 5, 2007·Physical Medicine and Rehabilitation Clinics of North America·Frances M Weaver, Sherri L LaVela
Jan 26, 2017·Annals of Rehabilitation Medicine·Soo Ho Park, Kang Hee Cho
Mar 15, 2006·Prostate Cancer and Prostatic Diseases·H B ShimJ H Ku
Nov 5, 2014·Spinal Cord·D J Allison, D S Ditor
Jul 27, 1999·American Journal of Physical Medicine & Rehabilitation·D I CampagnoloS E Keller
Nov 25, 2004·Anesthesia and Analgesia·Harish S LecamwasamPeter F Dunn
Apr 1, 2000·American Journal of Physical Medicine & Rehabilitation·T R DillinghamS Shannon
Jun 16, 2009·Neuroreport·Chia-Mao ChangJen-Tsung Yang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.