Impaired immune defense in hemodialysis patients: role of α-defensins?

Hemodialysis International
Clemens GruppGerhard A Mueller

Abstract

The mechanisms underlying the impaired immune response in hemodialysis (HD) patients are not completely understood. The α-defensins human neutrophil peptides-1, 2, and 3 are low molecular weight peptides with antimicrobial activity and important effector molecules of innate immune responses. We now examined the expression of these peptides in HD patients. Seventy-six patients on chronic HD treatment (mean time on HD 5.8 years; mean age 70 years) were studied and compared with 38 healthy volunteers and 20 patients with infections and normal renal function. Expression of α-defensins was analyzed semiquantitatively in leukocytes on the messenger RNA (mRNA) level by reverse transcriptase polymerase chain reaction; the α-defensin protein levels in serum were detected by enzyme-linked immunosorbent assay. α-Defensin concentrations (140 ± 10.5 ng/mL; mean ± standard error of the mean) as well as mRNA levels in leukocytes (82.9 ± 7.9 arbitrary units [a.u.]) in HD patients were not significantly different from those in healthy volunteers (156 ± 15.2 ng/mL; 81.4 ± 11.3 a.u.). Defensin levels were independent of the time of the patient on HD and their age. During infection periods (mean increase of the C-reactive protein to 161 ± 17.3 mg/...Continue Reading

References

May 1, 1995·Pharmacology & Therapeutics·T Ganz, R I Lehrer
Aug 1, 1994·Current Opinion in Immunology·T Ganz, R I Lehrer
Feb 27, 1999·Current Opinion in Immunology·R I Lehrer, T Ganz
Mar 23, 2000·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·G Fernández-FresnedoM Arias
Apr 12, 2002·The American Journal of Pathology·Claudia A MüllerThomas Flad
Oct 11, 2002·The New England Journal of Medicine·Michael Zasloff
Sep 17, 2004·Nature Reviews. Microbiology·Robert I Lehrer
Sep 28, 2007·Seminars in Dialysis·Theodoros EleftheriadisIoannis Stefanidis
Jan 24, 2008·The Journal of Clinical Endocrinology and Metabolism·Gowsini JosephJan Frystyk
Sep 18, 2009·Annals of the New York Academy of Sciences·Oren Froy, Zev M Sthoeger
Aug 24, 2010·Cell and Tissue Research·Linda Hazlett, Minhao Wu
Jan 14, 2011·Hemodialysis International·Seok-Hwan KimSun Ae Yoon
Dec 16, 2011·Immunological Reviews·Robert I Lehrer, Wuyuan Lu
Feb 24, 2012·PloS One·John David SpencerAndrew L Schwaderer
Sep 27, 2012·Journal of Cancer Research and Clinical Oncology·Mustafa GunesMehmet Aslan
Jun 13, 2013·Human Immunology·Justyna JarczakEmilia Bagnicka

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