Impaired immune response to Candida albicans in cells from Fanconi anemia patients

Cytokine
Alessia ParodiEnrico Cappelli

Abstract

Fanconi anemia (FA) is a genetic disorder characterized by bone marrow failure and cancer predisposition. Several studies show alterations of the immunological status of FA patients including defects in peripheral blood lymphocyte subsets, serum immunoglobulin levels, and inflammatory cytokines. However scanty information is available on the response of FA cells to specific infectious antigens. In this work we examined the response of FA cells to different immunological stimuli and found a defective response of IL-1β, TNF-α and IL-17 to Candida albicans stimulation thus pointing to a potentially impaired response to fungal infections of FA patients.

References

Mar 12, 2011·Nature Reviews. Immunology·Luigina Romani
May 6, 2011·British Journal of Haematology·Kasiani C MyersParinda A Mehta
May 23, 2012·Cell Host & Microbe·Nydiaris Hernández-Santos, Sarah L Gaffen
Mar 14, 2013·American Journal of Hematology·Elisabeth T KorthofEnrico Cappelli
Aug 9, 2013·The Journal of Clinical Investigation·Liping HuElizabeth A Eklund
Aug 13, 2013·Trends in Molecular Medicine·Enrico CappelliPaolo Degan
Sep 12, 2013·Cytokine·Graça A JustoVivian M Rumjanek
Feb 7, 2014·Blood·Wei DuQishen Pang
Jan 30, 2015·Scientific Reports·Cesare UsaiPaolo Degan

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Citations

May 31, 2017·Genetics and Molecular Biology·Anna GueiderikhJanuario B C Neto
Nov 14, 2018·HIV Clinical Trials·Chiara DentoneUNKNOWN ICONA Foundation Study Group

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