PMID: 3978240Mar 1, 1985Paper

Impaired in vitro growth of PHA induced T lymphocyte colonies in hemodialyzed renal failure patients

R GhioP Boccaccio


Using an in vitro method that allows the study of the colony forming capacity of phytohemagglutinin stimulated peripheral blood T lymphocytes, we have detected an impaired T cell colony formation in hemodialyzed renal failure patients. By contrast a near normal pattern of responses was observed in patients treated with a conservative therapy. The poor in vitro T cell responsiveness of hemodialyzed patients was not corrected by supplementing the cultures with an adherent cell contitioned medium prepared from normal donors. We conclude that an intrinsic defect of the T cell colony forming capacity exists in hemodialyzed patients.


Sep 1, 1977·European Journal of Immunology·M H ClaëssonA W Burgess
Aug 1, 1976·Kidney International·L J QuadracciM Krzymanski
Feb 1, 1976·The Australian Journal of Experimental Biology and Medical Science·J D Wilson, G Dalton
Dec 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·E Gerassi, L Sachs
Apr 1, 1980·Arthritis and Rheumatism·M L BernsteinS A Dobson
Jan 1, 1980·Scandinavian Journal of Immunology·G W CanonicaL Moretta
Dec 1, 1981·Clinical Immunology and Immunopathology·V PistoiaL Moretta
Oct 1, 1958·British Journal of Haematology·O JENSSON

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