Impaired increases in skin sympathetic nerve activity contribute to age-related decrements in reflex cutaneous vasoconstriction

The Journal of Physiology
Jody L GreaneyLacy M Alexander

Abstract

The reduction in skin blood flow during whole-body cooling is impaired in healthy older adults. However, the relative contributions of altered skin sympathetic nerve activity (SSNA), transduction of this efferent neural outflow to the cutaneous vasculature, and peripheral vascular responsiveness to adrenergic stimuli to the impaired reflex vasoconstrictor response to whole-body cooling in human ageing remain unclear. We report that the SSNA response to whole-body cooling is blunted in healthy older adults, and this attenuated sympathetic response is related to a marked impairment in reflex cutaneous vasoconstriction. Further, the reflex SSNA response to a non-thermoregulatory stimulus was preserved in older adults during cooling. We additionally show that cutaneous vascular responsiveness to adrenergic stimuli is not reduced in older adults. These results further our understanding of the physiological mechanisms underlying impaired thermal-cardiovascular integration in healthy ageing. Reflex cutaneous vasoconstriction is impaired in older adults; however, the relative roles of altered skin sympathetic nerve activity (SSNA) and end-organ peripheral vascular responsiveness are unclear. We hypothesized that in older adults whole-b...Continue Reading

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Citations

Nov 4, 2015·The Journal of Physiology·Daniel GagnonCraig G Crandall
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Dec 3, 2015·Autonomic Neuroscience : Basic & Clinical·Jody L GreaneyLacy M Alexander
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Sep 16, 2017·Journal of Applied Physiology·Jody L GreaneyLacy M Alexander
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May 18, 2021·Temperature : Multidisciplinary Biomedical Journal·Jody L GreaneyW Larry Kenney

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