PMID: 15377888Sep 21, 2004Paper

Impaired induction of IL-10 expression in the lung following hemorrhagic shock

Shock
Rachel G KhadarooOri D Rotstein

Abstract

The balance between pro- and anti-inflammatory cytokines is considered to be an important determinant of the magnitude of inflammation in a number of disease states. We previously showed that resuscitated hemorrhagic shock augmented LPS-induced release of proinflammatory molecules by alveolar macrophages (AM). In the present studies, we evaluated the expression and regulation of the counter inflammatory cytokine IL-10 in the lung using this model. We hypothesized that impaired up-regulation of IL-10 in shock/resuscitated animals might serve as a mechanism contributing to accentuated lung inflammation. In a rodent model, animals exposed to LPS alone exhibited enhanced IL-10 mRNA levels in lung tissue as well as in AM, but antecedent shock/resuscitation delayed and attenuated the LPS-induced IL-10 mRNA levels. The ability of shock to attenuate LPS-stimulated IL-10 was also seen in the protein levels. This effect correlated with an augmented expression of cytokine-induced neutrophil chemoattractant (CINC) mRNA. Shock/resuscitated animals given exogenous IL-10 had reduced proinflammatory response, as shown by decreased expression of CINC mRNA and decreased neutrophil sequestration in the lung. Shock/resuscitation plus LPS markedly ...Continue Reading

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Citations

Aug 19, 2006·The Journal of Trauma·Jennifer M WattersMartin A Schreiber
Sep 29, 2009·Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine·Michael FrinkFrank Hildebrand
Mar 29, 2014·Shock·Ulrike NieslerMarkus S Huber-Lang
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Sep 30, 2009·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·C I FernandesH P Souza
Apr 16, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Peng XuJie Fan

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