Impaired Insulin Suppression of VLDL-Triglyceride Kinetics in Nonalcoholic Fatty Liver Disease

The Journal of Clinical Endocrinology and Metabolism
Marianne K PoulsenSøren Nielsen

Abstract

Nonalcoholic fatty liver disease (NAFLD) is associated with glucose and lipid metabolic abnormalities. However, insulin suppression of very low-density lipoprotein-triglyceride (VLDL-TG) kinetics is not fully understood. The objective of the study was to determine VLDL-TG, glucose, and palmitate kinetics during fasting and hyperinsulinemia in men with (NAFLD+) and without NAFLD (NAFLD−). Twenty-seven nondiabetic, upper-body obese (waist to hip ratio > 0.9, body mass index > 28 kg/m2) men, 18 NAFLD+, and nine NAFLD− determined by magnetic resonance spectroscopy were enrolled.14C-labeled VLDL-TG and 3H-labeled glucose and palmitate tracers were applied in combination with indirect calorimetry and breath samples to assess kinetics and substrate oxidations postabsorptively and during a hyperinsulinemic-euglycemic clamp. Dual-X-ray absorptiometry and magnetic resonance imaging assessed body composition. Liver fat content was greater in NAFLD+ than NAFLD− men (21.0% vs 3.7%), even though body composition, metabolites (except triglycerides), and insulin were similar in the groups. Insulin suppression of VLDL-TG secretion (P = .0001), oxidation (P = .0003), and concentration (P= .008) as well as percentage decreases were lower in NAFLD...Continue Reading

Citations

Sep 19, 2016·Lipids in Health and Disease·Sabina Paglialunga, Clayton A Dehn
Dec 6, 2016·International Journal of Obesity : Journal of the International Association for the Study of Obesity·S HeebøllA Handberg
May 18, 2019·Endocrine Reviews·Matthew J WattMagdalene K Montgomery
Aug 14, 2019·The Journal of Clinical Endocrinology and Metabolism·Kelli A LytleMichael D Jensen
Jan 30, 2020·Acta Pharmaceutica Sinica. B·Tingting YanFrank J Gonzalez
Apr 20, 2020·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Christian Cortés-RojoElizabeth Calderón-Cortés
Mar 7, 2021·Journal of Clinical Medicine·Eric HajduchFabienne Foufelle
Oct 4, 2020·Molecular Metabolism·Audrey DeprinceBart Staels
May 1, 2021·International Journal of Molecular Sciences·Yoshitaka SakuraiTakashi Kadowaki
Apr 24, 2021·Molecular Metabolism·Joerg Heeren, Ludger Scheja
Nov 30, 2016·Current Opinion in Lipidology·Elias BjörnsonJan Borén

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