PMID: 2487403Jan 1, 1989Paper

Impaired interleukin-2 receptor expression on lymphocytes from patients with chronic active hepatitis type B

The Korean Journal of Internal Medicine
D S AhnD G Kim

Abstract

To evaluate cell mediated immunopathogenic mechanisms in chronic hepatitis B virus (HBV) infection, we investigated the changes of T4/T8 ratios from the peripheral blood, the percentages of IL-2 receptor expression after stimulation of mitogens (Con A, PHA) and a specific antigen (Hepatitis type B surface antigen, HBs), and the proliferative response mediated by IL-2 receptors after rIL-2 stimulation on mixed mononuclear cell. These experiments were performed comparatively in 5 groups which consisted of serologically negative normal subjects, chronic HBV carriers, patients with chronic active hepatitis (CAH) type B, patients with acute hepatitis (AH) type B, and the antibody positive healthy subjects. There were significant decreases of T4/T8 ratios in chronic HBV carriers, in patients with CAH type B, and in patients with AH type B, compared with negative normal controls. There were no significant differences between patients with CAH type B and the HBs negative normal controls in the percentage of IL-2 receptor positive cells after in-vitro HBs-stimulation and the proliferative response assessed by the incorporation of 3H-thymidine, whereas in patients with AH type B there were significant increases in both. Thus, in addition...Continue Reading

References

Nov 1, 1983·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·F G RegensteinR P Perrillo
Mar 1, 1982·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H C ThomasS Sherlock
Dec 1, 1983·The Journal of Experimental Medicine·D A Cantrell, K A Smith
Nov 1, 1981·The Journal of Experimental Medicine·R J RobbK A Smith
Jan 1, 1980·Immunological Reviews·K A Smith

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Citations

Dec 17, 2008·Scandinavian Journal of Gastroenterology·Chung-Pin LiShou-Dong Lee
Jan 21, 2006·World Journal of Gastroenterology : WJG·Ze-Xiong ChenYan-Li Gu

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