Impaired left ventricular diastolic function in T2DM patients is closely related to glycemic control

Endocrinology, Diabetes & Metabolism
Geoffrey D ClarkeRalph A DeFronzo

Abstract

Left ventricular (LV) diastolic dysfunction commonly is observed in individuals with type 2 diabetes mellitus (T2DM). We employed transthoracic echocardiography (TTE) and cardiac magnetic resonance imaging (CMRI) to investigate the hypothesis that LV diastolic dysfunction in T2DM is associated with poor glycemic control. Forty subjects, 21 with normal glucose tolerance (NGT) and 19 with T2DM, were studied with CMRI and TTE to assess LV function. Early-to-late transmitral flow ratio (E/A) and deceleration time (DecT) were assessed with both modalities. Normalized (to body surface area) end-diastolic volume (EDV/BSA) and normalized peak LV filling rate (pLVFR/BSA) were assessed with CMRI. Early transmitral flow velocity to septal velocity (E/e') and isovolumetric relaxation time (IVRT) were measured using TTE. Dimensional parameters were normalized to body surface area (BSA). CMRI measurements demonstrated impaired E/A (1.13 ± 0.34 vs 1.62 ± 0.42, P < .001), increased DecT (174 ± 46 ms vs 146 ± 15, P = .005), as well as lower EDV/BSA (63 ± 10 vs 72 ± 9 mL/m2, P < .01) and pLVFR/BSA (189 ± 46 vs 221 ± 48 mL s-1 m-2, P < .05) in T2DM subjects. TTE measurements revealed lower E/A (1.1 ± 0.4 vs 1.4 ± 0.2, P < .001) and E/e' (6.8 ± 1....Continue Reading

References

Oct 1, 1980·Circulation·Y Hirota
Apr 1, 1997·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·J K OhA J Tajik
Sep 15, 2000·Cardiology Clinics·E L Yellin, J S Meisner
Jan 3, 2001·Journal of Applied Physiology·M S FirstenbergM J Garcia
Apr 17, 2001·BMJ : British Medical Journal·G BeeversE O'Brien
Jul 9, 2005·European Radiology·Peter D GatehouseDavid N Firmin
Mar 21, 2006·Metabolism: Clinical and Experimental·Johan VerbraeckenLuc Van Gaal
Jul 21, 2006·The New England Journal of Medicine·Theophilus E OwanMargaret M Redfield
Nov 9, 2006·JAMA : the Journal of the American Medical Association·Francesca BursiVéronique L Roger
Feb 19, 2008·Journal of the American College of Cardiology·Steven J LesterJames B Seward
Jul 10, 2008·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Vikas K RathiRobert Ww Biederman
Feb 4, 2009·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Sherif F NaguehArturo Evangelista
Apr 8, 2010·Journal of Magnetic Resonance Imaging : JMRI·Ramkumar KrishnamurthyRaja Muthupillai
Jan 25, 2011·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Jérôme CaudronJean-Nicolas Dacher
Mar 25, 2011·The New England Journal of Medicine·Ralph A DeFronzoUNKNOWN ACT NOW Study
Dec 3, 2011·Journal of Cardiovascular Disease Research·Virendra C PatilPruthvi Shetty
Jan 21, 2012·Circulation·Dalane W Kitzman, William C Little
May 28, 2013·Cardiology in Review·Wael A AlJaroudiWael A Jaber
Dec 21, 2013·Diabetes Care·UNKNOWN American Diabetes Association

❮ Previous
Next ❯

Software Mentioned

RStudio IDE
R
CMR42

Related Concepts

Related Feeds

Biomarkers for Type 2 Diabetes

Biomarkers can help understand chronic diseases and assist in risk prediction for prevention and early detection of diseases. Here is the latest research on biomarkers in type 2 diabetes, a disease in which the body is unable to produce or properly use insulin.