Impaired leptomeningeal collateral flow contributes to the poor outcome following experimental stroke in the Type 2 diabetic mice

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Yosuke AkamatsuJialing Liu

Abstract

Collateral status is an independent predictor of stroke outcome. However, the spatiotemporal manner in which collateral flow maintains cerebral perfusion during cerebral ischemia is poorly understood. Diabetes exacerbates ischemic brain damage, although the impact of diabetes on collateral dynamics remains to be established. Using Doppler optical coherent tomography, a robust recruitment of leptomeningeal collateral flow was detected immediately after middle cerebral artery (MCA) occlusion in C57BL/6 mice, and it continued to grow over the course of 1 week. In contrast, an impairment of collateral recruitment was evident in the Type 2 diabetic db/db mice, which coincided with a worse stroke outcome compared with their normoglycemic counterpart db/+, despite their equally well-collateralized leptomeningeal anastomoses. Similar to the wild-type mice, both db/+ and db/db mice underwent collateral growth 7 d after MCA stroke, although db/db mice still exhibited significantly reduced retrograde flow into the MCA territory chronically. Acutely induced hyperglycemia in the db/+ mice did not impair collateral flow after stroke, suggesting that the state of hyperglycemia alone was not sufficient to impact collateral flow. Human albumin ...Continue Reading

Citations

Nov 12, 2016·Stroke; a Journal of Cerebral Circulation·Yasuo NishijimaJialing Liu
Jan 21, 2016·Stroke; a Journal of Cerebral Circulation·Daniel J BeardNeil J Spratt
Jul 25, 2019·Stroke; a Journal of Cerebral Circulation·Philippe BonninNathalie Kubis
Mar 31, 2015·Stroke; a Journal of Cerebral Circulation·Jialing Liu
Jul 17, 2020·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Atsushi KanokeJialing Liu
Aug 29, 2019·Biomedical Engineering Letters·Woo June Choi
Feb 3, 2016·Neurophotonics·Utku Baran, Ruikang K Wang
Oct 26, 2018·Stroke; a Journal of Cerebral Circulation·Joon-Tae KimJeffrey L Saver
Oct 26, 2018·Stroke; a Journal of Cerebral Circulation·Shubei MaJun Chen
Jan 4, 2020·The Neuroradiology Journal·Gregory A ChristoforidisAndrew P Slivka
Nov 4, 2020·Translational Stroke Research·Yinghua JiangXiaoying Wang
Feb 28, 2021·Annals of the New York Academy of Sciences·Matthew J Krinock, Neel S Singhal
Jun 4, 2021·Stroke; a Journal of Cerebral Circulation·Nabil J Alkayed, Marilyn J Cipolla
Sep 17, 2021·Diabetes/metabolism Research and Reviews·Sian A BradleySonu M M Bhaskar

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