PMID: 2495180Jan 1, 1989Paper

Impaired local natural killer cell activity in human colorectal carcinomas

Cancer Immunology, Immunotherapy : CII
N M Aparicio-PagésC B Lamers

Abstract

The present study was undertaken to study natural killer (NK) cell activity in patients with colorectal cancer at peripheral and local levels. Mononuclear cells were isolated from uninvolved colorectal mucosa, tumor tissue and peripheral blood, and tested against the colon carcinoma cell line CaCo-2 and the erythroleukemia cell line K-562. Peripheral blood NK cell activity from the patients showed similar levels compared with healthy controls, whereas, mononuclear cells of tumor tissue were found to have a significantly decreased NK cell activity compared to the normal intestinal mucosa (P less than 0.01). No relation was found between the NK cell activity and the advancement of the disease according to the Duke's stage. Interferon-gamma (IFN-gamma) stimulated the NK cell activity of the mononuclear cells from blood, mucosa and tumor. However, the increase of NK cell activity after IFN-gamma stimulation was lower in the tumor compared to the mucosa (P less than 0.02). The lectin, phytohaemagglutinin, increased the cytotoxicity of mononuclear cells from blood, mucosa and tumor to a similar level. These results suggest that patients with colorectal tumors exhibit a normal NK cell activity in peripheral blood and intestinal mucosa...Continue Reading

Citations

Jan 1, 1989·Cancer Immunology, Immunotherapy : CII·G GuantiI Giorgio
Feb 9, 2005·Journal of Translational Medicine·Christine V Ichim
Oct 1, 1993·Surgical Oncology·S S Somers, P J Guillou
Feb 6, 2015·BMC Complementary and Alternative Medicine·Jing LiuChunying Li
Mar 10, 2001·The American Journal of Gastroenterology·H TakeuchiK Sugimachi
Apr 1, 1996·Cancer·J BrittendenO Eremin

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