Impaired long-term maintenance and function of Bordetella pertussis specific B cell memory

Vaccine
Rachel M StengerCécile A C M van Els

Abstract

Frequent occurrence of whooping cough in vaccinated populations suggests limited duration of vaccine-induced immunological memory. To investigate peculiarities in B cell memory specific for pertussis antigens P.69 pertactin (P.69 Prn), pertussis toxin (Ptx) and filamentous hemagglutinin (FHA), we monitored the induction and maintenance of specific serum IgG, long-lived bone marrow (BM)-derived plasma cell (PC) and splenic memory B cell (B(mem)) populations in a long-term preclinical vaccination model. Groups of BALB/c mice were primed and boosted (day 28) with a combined diphtheria (D), tetanus (T), acellular pertussis (aP) vaccine (DTaP) or whole cell pertussis (P) vaccine (DTP) and the immune status was followed over time. Levels of pertussis specific IgG, induced after primary and booster immunization, peaked at day 98 to decline thereafter. This was not paralleled by a decay, but rather an increase in BM resident specific PC, over time (>1 year). In contrast, splenic B(mem) peaked after booster immunization to decline till background levels. Late recall of immunological memory more than 1 year after primary and booster vaccination, however, did reveal a rapid proliferative response of pre-existing B(mem) but failed to evoke...Continue Reading

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Citations

Jun 15, 2014·Drugs & Aging·Pierre-Olivier Lang, Richard Aspinall
Aug 21, 2013·Archivum Immunologiae Et Therapiae Experimentalis·Giorgio FedeleClara Maria Ausiello
Aug 4, 2012·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Wouter F TonnisJean-Pierre Amorij
Nov 16, 2012·Expert Review of Vaccines·Arno Aj van der ArkCécile A C M van Els
Nov 3, 2011·Expert Review of Vaccines·Jan T PoolmanScott A Halperin
Sep 30, 2015·Pathogens and Disease·Erich V Scheller, Peggy A Cotter
Sep 9, 2015·Pathogens and Disease·Jolanda BrummelmanKingston H G Mills
Jun 21, 2015·Current Opinion in Immunology·Jason M Warfel, Kathryn M Edwards
Mar 16, 2017·Cold Spring Harbor Perspectives in Biology·Nicolas BurdinStanley A Plotkin

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