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Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in neurons from patients with Alzheimer's disease: implications for neuronal damage

Human Molecular Genetics

Apr 5, 2011

Maria ManczakP Hemachandra Reddy

Abstract

The purpose of our study was to better understand the relationship between mitochondrial structural proteins, particularly dynamin-related protein 1 (Drp1) and amyloid beta (Aβ) in the progression of Alzheimer's disease (AD). Using qRT-PCR and immunoblotting analyses, we measured mRNA a...read more

Mentioned in this Paper

Hippocampus (Brain)
CRMP1 gene
DENR gene
DNM1L gene
OPA1 gene
PPID gene
UTRN gene
MFN2 gene
TOMM40 gene
MFN1 gene
215
Paper Details
References
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  • Citations134
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  • References51
  • Citations134
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Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in neurons from patients with Alzheimer's disease: implications for neuronal damage

Human Molecular Genetics

Apr 5, 2011

Maria ManczakP Hemachandra Reddy

PMID: 21459773

DOI: 10.1093/hmg/ddr139

Abstract

The purpose of our study was to better understand the relationship between mitochondrial structural proteins, particularly dynamin-related protein 1 (Drp1) and amyloid beta (Aβ) in the progression of Alzheimer's disease (AD). Using qRT-PCR and immunoblotting analyses, we measured mRNA a...read more

Mentioned in this Paper

Hippocampus (Brain)
CRMP1 gene
DENR gene
DNM1L gene
OPA1 gene
PPID gene
UTRN gene
MFN2 gene
TOMM40 gene
MFN1 gene
215

Related Papers

Paper Details
References
  • References51
  • Citations134
12345...
  • References51
  • Citations134
12345...
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