PMID: 9420661Sep 1, 1995Paper

Impaired mitochondrial function in idiopathic dilated cardiomyopathy: biochemical and molecular analysis

Journal of Cardiac Failure
J Marin-GarciaR Ananthakrishnan

Abstract

Mitochondrial defects at the biochemical and molecular levels are increasingly recognized in diseases involving the heart. The objective of this study was to assess the frequency and extent of mitochondrial defects in idiopathic dilated cardiomyopathy. Left ventricular tissues of 27 patients with idiopathic dilated cardiomyopathy undergoing orthotopic cardiac transplantation because of severe cardiac failure were examined to assess the specific activity levels of mitochondrial respiratory enzymes and changes in mtDNA structure and copy number. Abnormal specific activities of several mitochondrial enzymes were found in 55% of the cardiomyopathic tissues examined (15 patients), with six patients displaying single enzyme defects, including five in complex III and one in complex I. Multiple mitochondrial enzyme defects were found in nine patients, with the most frequent combination of defects seen in complex III and complex IV (5 cases). These enzymatic changes were shown not to be accompanied by changes in mtDNA copy number. In seven cases, however, including three young adults, there was a marked decrease in the levels of polymerase chain reaction products derived from specific mtDNA regions, which may be an indication of specifi...Continue Reading

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Citations

Jan 1, 1996·Journal of Inherited Metabolic Disease·J Marin-GarciaA Perez-Atayde
Jul 24, 2010·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Billie A MooreTamara Caspary
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Jul 1, 1998·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·J Marin-Garcia, M J Goldenthal
Mar 21, 2000·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·J Marin-GarciaA Perez-Atayde
Apr 4, 2000·Journal of Cardiac Failure·A F QuigleyE Byrne
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Apr 8, 2021·Scientific Reports·Maria Calderon-DominguezRocio Toro

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