Impaired monocyte IL-12 production before surgery as a predictive factor for the lethal outcome of postoperative sepsis

Annals of Surgery
H WeighardtB Holzmann

Abstract

To investigate whether monocyte paralysis resistant to interferon-gamma (IFN-gamma) costimulation may exist before surgery and postoperative infection and may correlate with the outcome of postoperative sepsis. Several studies have correlated monocyte paralysis during the course of sepsis with lethal outcome. Although the authors' previous work indicated that preoperative defects in monocyte interleukin (IL)-12 production are associated with the development of severe postoperative sepsis, the functional state of monocytes before surgery and infection and its significance for sepsis requires further analysis. In a prospective study, monocyte functions of 1,113 consecutive patients were examined before major visceral surgery. Monocytes were isolated from peripheral blood and were stimulated in vitro with IFN-gamma and lipopolysaccharide. The secretion of IL-12 p70, IL-12 p40, IL-10, and tumor necrosis factor was measured. Preoperative monocyte secretion of IL-12 p70 and IL-12 p40 was significantly reduced in patients who developed lethal postoperative sepsis compared with sepsis survivors and patients with uneventful postoperative recovery. Moreover, preoperative monocyte IL-12 production was an independent predictive factor for ...Continue Reading

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Citations

Aug 12, 2005·Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen·A NovotnyB Holzmann
Jul 5, 2005·Langenbeck's Archives of Surgery·Martin K Angele, Irshad H Chaudry
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