Impaired mouse mammary gland growth and development is mediated by melatonin and its MT1G protein-coupled receptor via repression of ERα, Akt1, and Stat5.

Journal of Pineal Research
Shulin XiangSteven M Hill

Abstract

To determine whether melatonin, via its MT(1)  G protein-coupled receptor, impacts mouse mammary gland development, we generated a mouse mammary tumor virus (MMTV)-MT1-Flag-mammary gland over-expressing (MT1-mOE) transgenic mouse. Increased expression of the MT(1) -Flag transgene was observed in the mammary glands of pubescent MT1-mOE transgenic female mice, with further significant increases during pregnancy and lactation. Mammary gland whole mounts from MT1-mOE mice showed significant reductions in ductal growth, ductal branching, and terminal end bud formation. Elevated MT(1) receptor expression in pregnant and lactating female MT1-mOE mice was associated with reduced lobulo-alveolar development, inhibition of mammary epithelial cell proliferation, and significant reductions in body weights of suckling pups. Elevated MT(1) expression in pregnant and lactating MT1-mOE mice correlated with reduced mammary gland expression of Akt1, phospho-Stat5, Wnt4, estrogen receptor alpha, progesterone receptors A and B, and milk proteins β-casein and whey acidic protein. Estrogen- and progesterone-stimulated mammary gland development was repressed by elevated MT(1) receptor expression and exogenous melatonin administration. These studie...Continue Reading

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Citations

Jan 22, 2013·Journal of Pineal Research·Karolina JablonskaPiotr Dziegiel
Oct 9, 2013·Cancer Letters·Fergal C KelleherAnne Maguire
Sep 22, 2018·Journal of Cellular Physiology·Bagher FarhoodAmirhossein Sahebkar
Oct 23, 2018·Biology of Reproduction·Wenlong ZhangDewen Tong
Sep 4, 2018·Frontiers in Physiology·Tina NapsoAmanda N Sferruzzi-Perri
Dec 8, 2020·Frontiers in Cell and Developmental Biology·Min TianShihai Zhang

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