PMID: 8598042Feb 23, 1996Paper

Impaired negative selection of T cells in Hodgkin's disease antigen CD30-deficient mice

Cell
R AmakawaT W Mak

Abstract

CD30 is found on Reed-Sternberg cells of Hodgkin's disease and on a variety of non-Hodgkin's lymphoma cells and is up-regulated on cells after Epstein-Barr virus, human T cell leukemia virus, and HIV infections. We report here that the thymus in CD30-deficient mice contains elevated numbers of thymocytes. Activation-induced death of thymocytes after CD3 cross-linking is impaired both in vitro and in vivo. Breeding the CD30 mutation separately into alpha beta TCR-or gamma delta TCR-transgenic mice revealed a gross defect in negative but not positive selection. Thus, like TNF-receptors and Fas/Apo-1, the CD30 receptor is involved in cell death signaling. It is also an important coreceptor that participates in thymic deletion.

References

Nov 1, 1992·Genomics·C FonatschH Stein
Dec 1, 1992·The Journal of Experimental Medicine·V A WallaceT W Mak
Apr 1, 1990·Histopathology·G Pallesen
Oct 15, 1990·Cancer·G Mechtersheimer, P Möller
Sep 1, 1990·Histopathology·M PirisD Y Mason
Jun 30, 1989·Cell·R H Schwartz
Jan 1, 1988·Immunological Reviews·J SprentY Ron
Oct 15, 1982·International Journal of Cancer. Journal International Du Cancer·H SteinV Diehl
Aug 1, 1994·The Journal of Experimental Medicine·M V Clement, I Stamenkovic
Apr 1, 1995·Current Opinion in Immunology·J Sprent, S R Webb
Nov 1, 1995·The Journal of Experimental Medicine·T M FoyR J Noelle
May 19, 1995·Cell·J L Cleveland, J N Ihle
Apr 1, 1994·Current Opinion in Immunology·M F Bachmann, T M Kündig
Jan 1, 1994·Annual Review of Immunology·E Robey, B J Fowlkes
Feb 11, 1993·Nature·J P DiSantoG de Saint Basile

❮ Previous
Next ❯

Citations

Dec 26, 2001·European Journal of Immunology·Sandrine GuerinPhilippe Naquet
Jan 1, 1996·International Journal of Clinical & Laboratory Research·H J Gruss
Feb 6, 2003·International Journal of Hematology·Ryouichi HorieToshiki Watanabe
Oct 11, 2005·Apoptosis : an International Journal on Programmed Cell Death·T AbdollahiG Litwack
Nov 16, 2013·Immunologic Research·Hiromi Muta, Eckhard R Podack
Nov 25, 2003·Current Opinion in Immunology·Pamela S Ohashi
Dec 11, 2002·Cellular Immunology·Sang Yun NamEckhard R Podack
Mar 22, 2000·Journal of Immunological Methods·N HollerP Schneider
Sep 21, 2000·Immunology Letters·F OssendorpC J Melief
Aug 23, 2000·Immunology Today·P RomagnaniS Romagnani
Jul 1, 1997·Immunology Today·C Ardavín
Jun 1, 1997·Immunology Today·S Romagnani
Oct 7, 1998·Neurochemistry International·G FábiánM Szucs
Sep 1, 1996·Research in Immunology·J P Abastado
Jan 9, 1998·Baillière's Clinical Haematology·P G Ekert, D L Vaux
Jun 19, 2001·Current Opinion in Immunology·G A Bishop, B S Hostager
Jun 19, 2001·Current Opinion in Immunology·R C Budd
Dec 24, 2002·Current Opinion in Immunology·Chris A BenedictCarl F Ware
Nov 5, 2002·Current Opinion in Immunology·Fabienne Mackay, Susan L Kalled
Dec 1, 1996·Current Opinion in Immunology·J F Miller, A Basten
Jun 1, 1997·Current Opinion in Immunology·B Wong, Y Choi
Jun 1, 1997·Current Opinion in Immunology·A Winoto
Jun 1, 1997·Current Opinion in Immunology·E W Shores, P E Love
Apr 1, 1997·Current Opinion in Immunology·P Marrack, J Kappler
Jun 6, 2003·Cytokine & Growth Factor Reviews·Chris A Benedict
Apr 27, 2001·Trends in Immunology·F AnnunziatoS Romagnani
Jul 16, 2003·Trends in Immunology·Yves ColletteDaniel Olive
Jun 26, 2001·Allergy·A Bengtsson
Oct 24, 2002·Tissue Antigens·L C Goldie-CreganL J Abraham
Feb 28, 2006·Nature Biotechnology·Daniella HerszfeldMartin F Pera
Jul 22, 2005·Nature Reviews. Immunology·Peter J L LaneMi-Yeon Kim
Sep 26, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T MasakiM Omata
Aug 1, 1996·The Journal of Experimental Medicine·H KishimotoJ Sprent
Nov 17, 1998·The Journal of Experimental Medicine·M RincónR A Flavell
Jun 8, 1999·The Journal of Experimental Medicine·P SchneiderJ Tschopp
Aug 3, 1999·The Journal of Experimental Medicine·H Kishimoto, J Sprent
Sep 18, 2002·The Journal of Experimental Medicine·Margarida SaraivaAntonio Alcami

❮ Previous
Next ❯

Related Concepts

Related Feeds

B cells: Gene Expression

B lymphocytes are white blood cells that play a role in the adaptive immune system by secreting antibodies. Here is the latest research on gene expression in B cells.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.

Cell eTOC

Cell is a scientific journal publishing research across a broad range of disciplines within the life sciences field. Discover the latest research from Cell here.

HIV/AIDS-Related Malignancies

HIV/AIDS infection increases the risk of non-communicable diseases common in the aged including HIV/AIDS-related malignancies. Discover the latest research in HIV/AIDS-related malignancies.