Impaired neural processing of dynamic faces in left-onset Parkinson's disease

Neuropsychologia
P Garrido-VásquezS A Kotz

Abstract

Parkinson's disease (PD) affects patients beyond the motor domain. According to previous evidence, one mechanism that may be impaired in the disease is face processing. However, few studies have investigated this process at the neural level in PD. Moreover, research using dynamic facial displays rather than static pictures is scarce, but highly warranted due to the higher ecological validity of dynamic stimuli. In the present study we aimed to investigate how PD patients process emotional and non-emotional dynamic face stimuli at the neural level using event-related potentials. Since the literature has revealed a predominantly right-lateralized network for dynamic face processing, we divided the group into patients with left (LPD) and right (RPD) motor symptom onset (right versus left cerebral hemisphere predominantly affected, respectively). Participants watched short video clips of happy, angry, and neutral expressions and engaged in a shallow gender decision task in order to avoid confounds of task difficulty in the data. In line with our expectations, the LPD group showed significant face processing deficits compared to controls. While there were no group differences in early, sensory-driven processing (fronto-central N1 an...Continue Reading

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Citations

Aug 9, 2016·Neuroscience and Biobehavioral Reviews·Caroline SeerBruno Kopp
Sep 28, 2016·Frontiers in Neurology·Maria C A SantosAnelyssa D'Abreu
Dec 4, 2016·Neuroscience and Biobehavioral Reviews·Catarina C KordsachiaJulie C Stout
Apr 23, 2020·Parkinson's Disease·Gulsum AkdenizOrhan Deniz
Jun 28, 2018·Frontiers in Human Neuroscience·Patricia Garrido-VásquezSonja A Kotz
Nov 28, 2020·Journal of the International Neuropsychological Society : JINS·Laura Alonso-RecioJuan Manuel Serrano

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