Abstract
Neuronal NO synthase (nNOS) regulates blood flow in resistance vasculature at rest and during mental stress. To investigate whether nNOS signaling is dysfunctional in essential hypertension, forearm blood flow responses to mental stress were examined in 88 subjects: 48 with essential hypertension (42±14 years; blood pressure, 141±17/85±15 mm Hg; mean±SD) and 40 normotensive controls (38±14 years; 117±13/74±9 mm Hg). A subsample of 34 subjects (17 hypertensive) participated in a single blind 2-phase crossover study, in which placebo or sildenafil 50 mg PO was administered before an intrabrachial artery infusion of the selective nNOS inhibitor S-methyl-l-thiocitrulline (SMTC, 0.05, 0.1, and 0.2 μmol/min) at rest and during mental stress. In a further subsample (n=21) with an impaired blood flow response to mental stress, responses were measured in the presence and absence of the α-adrenergic antagonist phentolamine. The blood flow response to mental stress was impaired in hypertensive compared with normotensive subjects (37±7% versus 70±8% increase over baseline; P<0.001). SMTC blunted responses to mental stress in normotensive but not in hypertensive subjects (reduction of 40±11% versus 3.0±14%, respectively, P=0.01, between gro...Continue Reading
References
Jan 11, 1975·IEEE Transactions on Bio-medical Engineering·D E HokansonD E Strandness
Jan 1, 1990·Journal of Clinical Epidemiology·M H AldermanH Cohen
Jul 5, 1990·The New England Journal of Medicine·J A PanzaS E Epstein
Oct 28, 1989·Lancet·P VallanceS Moncada
Sep 1, 1987·The Journal of Clinical Investigation·B EganS Julius
Dec 1, 1993·Journal of Hypertension·W G HaynesD J Webb
Oct 15, 1994·The Journal of Physiology·N M DietzM J Joyner
Apr 14, 1994·The New England Journal of Medicine·J R CockcroftJ M Ritter
Aug 1, 1996·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·J P FauvelP Zech
Nov 11, 1998·Journal of the American College of Cardiology·C CardilloJ A Panza
Mar 17, 1999·The American Journal of Cardiology·G JacksonM J Allen
Sep 15, 2001·Clinical Pharmacology and Therapeutics·V DishyC M Stein
Feb 19, 2002·Journal of the American College of Cardiology·Michel L HijmeringTon J Rabelink
Jun 25, 2003·Brain : a Journal of Neurology·Hugo D CritchleyRaymond J Dolan
Jul 23, 2003·British Journal of Pharmacology·Ian D WakefieldSheila M Gardiner
Feb 23, 2005·Hypertension·David M Pollock
Aug 31, 2006·Hypertension·James J OliverDavid J Webb
Sep 27, 2006·Handbook of Experimental Pharmacology·S Moncada, E A Higgs
May 1, 2007·Cardiovascular Research·David A KassHunter C Champion
Sep 8, 2007·Lancet·Daniel J BrotmanIlan S Wittstein
Feb 28, 2008·Journal of Hypertension·Teresa M AttinàDavid J Webb
Mar 7, 2008·Antioxidants & Redox Signaling·Eberhard SchulzThomas Münzel
Apr 9, 2008·Circulation·Michael D SeddonAjay M Shah
May 13, 2009·Circulation·Michael SeddonAjay M Shah
Dec 17, 2009·BJU International·Serap GurWayne J G Hellstrom
Mar 3, 2010·Hypertension·Yoichi Chida, Andrew Steptoe
May 8, 2010·Trends in Cardiovascular Medicine·Narbeh MelikianAjay M Shah
Nov 6, 2010·Journal of Applied Physiology·Christopher E SchwartzJason R Carter
Feb 26, 2013·American Journal of Physiology. Heart and Circulatory Physiology·Husain ShabeehPhil Chowienczyk
Feb 28, 2013·American Journal of Hypertension·John M DoppBradley G Phillips
Citations
Feb 27, 2016·The Journal of Physiology·Dan Li, David J Paterson
Nov 29, 2016·The Journal of Physiology·Jody L GreaneyLacy M Alexander
Jun 25, 2017·American Journal of Physiology. Heart and Circulatory Physiology·Sitara G KhanAjay M Shah
Mar 8, 2017·Hypertension·Husain ShabeehAjay M Shah
Mar 5, 2018·European Journal of Applied Physiology·Natalie G OrmshawJanice M Marshall
Feb 13, 2018·Experimental and Therapeutic Medicine·Yanhong MengYanhui Wang
May 16, 2020·Clinical Medicine : Journal of the Royal College of Physicians of London·Haseeb RahmanDivaka Perera
Mar 18, 2021·BMC Psychiatry·Marc J Kaufman, Garrett M Fitzmaurice
Jun 27, 2020·Nitric Oxide : Biology and Chemistry·Ahmmed AllySurya M Nauli
Jun 14, 2021·Cardiovascular Research·Kevin O'GallagherAjay M Shah