Impaired neurovascular coupling by transhemispheric diaschisis in rat cerebral cortex

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
Pia EnagerMartin Lauritzen

Abstract

In acute brain disorders, elimination of the excitatory output from an injured brain region reduces activity in connecting brain regions remote from the lesion site (i.e., diaschisis). The authors examined the effect of functional ablation of the left cerebral cortex by cortical spreading depression (CSD) or topical application of tetrodotoxin on single cell spiking activity, baseline CBF, and neurovascular coupling in the right rat sensory cortex. CSD or tetrodotoxin in left cortex reduced the right cortical spontaneous spike rate by 36% and 45%, respectively. Baseline CBF in the right cortex was unaffected by a left-sided CSD, but decreased by 12% for left cortical application of tetrodotoxin. This suggested dissociation between spontaneous spiking activity and basal CBF. Left in-fraorbital nerve stimulation evoked local field potentials in right cerebral cortex that were reduced in amplitude by 19% for left CSD and by 23% for left tetrodotoxin application. The corresponding declines in the evoked CBF responses were 42% for CSD and 23% for tetrodotoxin. Vascular reactivity to adenosine remained unchanged in right cortex. Thus, transhemispheric diaschisis produced a pronounced decrease in the spontaneous spike rate accompanied...Continue Reading

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Citations

Dec 22, 2004·Nature Reviews. Neuroscience·Martin Lauritzen
May 30, 2014·Brain : a Journal of Neurology·Emmanuel Carrera, Giulio Tononi
Feb 22, 2007·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Yawu LiuRitva L Vanninen
Aug 10, 2006·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Henrik W HoffmeyerMartin J Lauritzen
Jun 20, 2013·Child Neuropsychology : a Journal on Normal and Abnormal Development in Childhood and Adolescence·Eswen FavaHeather Bortfeld
Apr 6, 2018·International Journal of Molecular Medicine·Yu Wen LinE Jian Lee

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