Impaired nocifensive behaviours and mechanical hyperalgesia, but enhanced thermal allodynia in pituitary adenylate cyclase-activating polypeptide deficient mice

Neuropeptides
Katalin SandorZsuzsanna Helyes

Abstract

Pituitary adenylate cyclase-activating polypeptide-38 (PACAP-38) and its receptors (PAC1 and VPAC) have been shown in the spinal dorsal horn, dorsal root ganglia and sensory nerve terminals. Data concerning the role of PACAP in central pain transmission are controversial and we have recently published its divergent peripheral effects on nociceptive processes. The aim of the present study was to investigate acute somatic and visceral nocifensive behaviours, partial sciatic nerve ligation-evoked chronic neuropathic, as well as resiniferatoxin-induced inflammatory thermal and mechanical hyperalgesia in PACAP deficient (PACAP(-/-)) mice to elucidate its overall function in pain transmission. Neuronal activation was investigated with c-Fos immunohistochemistry. Paw lickings in the early (0-5 min) and late (20-45 min) phases of the formalin test were markedly reduced in PACAP(-/-) mice. Acetic acid-evoked abdominal contractions referring to acute visceral chemonociception was also significantly attenuated in PACAP knockout animals. In both models, the excitatory role of PACAP was supported by markedly greater c-Fos expression in the periaqueductal grey and the somatosensory cortex. In PACAP-deficient animals neuropathic mechanical hy...Continue Reading

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Citations

Apr 25, 2012·Journal of Molecular Neuroscience : MN·D ReglodiA Tamas
Nov 12, 2013·Neuropeptides·Eric A Kaiser, Andrew F Russo
Mar 9, 2018·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Amynah A PradhanSimon Akerman
Jan 25, 2018·The Journal of Pharmacology and Experimental Therapeutics·Ichiro TakasakiTakashi Kurihara
Oct 23, 2018·GeroScience·D ReglodiA Bardosi

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