Impaired oxidative metabolism and inflammation are associated with insulin resistance in ERalpha-deficient mice.

American Journal of Physiology. Endocrinology and Metabolism
Vicent RibasAndrea L Hevener

Abstract

Impaired estrogen action is associated with the metabolic syndrome in humans. We sought to determine whether impaired estrogen action in female C57Bl6 mice, produced by whole body Esr1 ablation, could recapitulate aspects of this syndrome, including inflammation, insulin resistance, and obesity. Indeed, we found that global knockout (KO) of the estrogen receptor (ER)alpha leads to reduced oxygen uptake and caloric expenditure compared with wild-type (WT) mice. In addition, fasting insulin, leptin, and PAI-1 levels were markedly elevated, whereas adiponectin levels were reduced in normal chow-fed KO. Furthermore, ERalpha-KO mice exhibited impaired glucose tolerance and marked skeletal muscle insulin resistance that was accompanied by the accumulation of bioactive lipid intermediates, inflammation, and diminished PPARalpha, PPARdelta, and UCP2 transcript levels. Although the relative glucose intolerance and insulin resistance phenotype in KO mice became more severe with high-fat feeding, WT mice were refractory to these dietary-induced effects, and this protection coincided with a marked increase in circulating adiponectin and heat shock protein 72 levels in muscle, liver, and fat. These data indicate that ERalpha is critical for...Continue Reading

References

Nov 11, 1992·The American Journal of Physiology·E A BanksJ L Ivy
Mar 1, 1992·Diabetes Care·R A DeFronzoE Ferrannini
Dec 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·P WalterM Waterfield
May 1, 1969·Analytical Biochemistry·J B Allred, D G Guy
Nov 1, 1984·Metabolism: Clinical and Experimental·H Yki-Järvinen
Jul 11, 1994·The American Journal of Physiology·J T BrozinickJ L Ivy
Oct 20, 1994·The New England Journal of Medicine·E P SmithK S Korach
Sep 11, 1993·The American Journal of Physiology·J T BrozinickJ L Ivy
Jun 1, 1996·The Journal of Clinical Investigation·A Vidal-PuigD E Moller
Dec 17, 1997·The Journal of Clinical Endocrinology and Metabolism·E EnmarkJ A Gustafsson
Mar 14, 1998·Bioorganicheskaia khimiia·I B MertsalovV I Tsetlin
Apr 16, 1998·Biochemical and Biophysical Research Communications·W H SunW B Ershler
Mar 7, 2000·Current Medicinal Chemistry·K DecheringS Mosselman
Aug 18, 2000·The Journal of Clinical Endocrinology and Metabolism·H W DengR R Recker
Nov 9, 2000·Proceedings of the National Academy of Sciences of the United States of America·P A HeineP S Cooke
Oct 27, 2001·Circulation Research·M J EvansD C Harnish
Dec 12, 2001·American Journal of Physiology. Endocrinology and Metabolism·Jonathan S FisherLorraine A Nolte
Feb 15, 2002·Endocrine Reviews·Johannes PfeilschifterHelmut Schatz
May 29, 2002·Diabetes·Andrea HevenerJerrold Olefsky
Jun 20, 2002·Endocrinology·Mark J EvansChristopher C Chadwick
Aug 10, 2002·American Journal of Physiology. Endocrinology and Metabolism·Morris F White
Nov 6, 2002·The Journal of Biological Chemistry·Yong Hee LeeMorris F White
Nov 26, 2002·Nature·Jiro HirosumiGökhan S Hotamisligil
Nov 29, 2002·Proceedings of the National Academy of Sciences of the United States of America·Eva TomasNeil B Ruderman
Apr 26, 2003·American Journal of Physiology. Heart and Circulatory Physiology·M R VossA A Knowlton
May 20, 2003·Journal of the American Geriatrics Society·Cathy C LeeMark A Supiano
Jun 6, 2003·The Journal of Clinical Endocrinology and Metabolism·Molly C Carr
Aug 15, 2003·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·T OkuraH Shimokata
Sep 25, 1959·Annals of the New York Academy of Sciences·R STEELE
Nov 20, 2003·Nature Medicine·Andrea L HevenerJerrold Olefsky
Dec 25, 2003·Diabetes·John M AdamsLawrence J Mandarino
Feb 13, 2004·Progress in Cardiovascular Diseases·Suzanne R Steinbaum
Jan 22, 2005·American Heart Journal·Phillippa J MirandaJohn R Guyton

❮ Previous
Next ❯

Citations

Sep 7, 2013·Reviews in Endocrine & Metabolic Disorders·E Fuente-MartinM H Tschöp
Sep 3, 2013·Frontiers in Neuroendocrinology·Jamaica R RettbergRoberta Diaz Brinton
Sep 9, 2011·Proceedings of the National Academy of Sciences of the United States of America·Vicent RibasAndrea L Hevener
Dec 30, 2010·American Journal of Physiology. Endocrinology and Metabolism·Daniel A KaneRonald N Cortright
Nov 30, 2012·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Kathryn C JacksonEspen E Spangenburg
Jan 15, 2011·Journal of Applied Physiology·Brittany K GorresPaige C Geiger
Apr 25, 2012·Medicine and Science in Sports and Exercise·Espen E SpangenburgDawn A Lowe
Nov 18, 2014·Mediators of Inflammation·Rosário MonteiroConceição Calhau
Mar 2, 2013·Journal of Applied Physiology·Kechun TangEllen C Breen
Mar 6, 2013·Endocrine Reviews·Franck Mauvais-JarvisAndrea L Hevener
May 31, 2012·International Journal of Colorectal Disease·A Joan LevineRobert W Haile
Jun 21, 2011·Heart Failure Reviews·Hong WangJian-Jun Li
Dec 25, 2015·Immunological Investigations·Asker Zeki OzsoyHatice Yılmaz Dogru
Oct 16, 2010·Obesity·Irene LambrinoudakiEvangelia Kouskouni
Oct 23, 2015·International Journal of Endocrinology·Minqian Shen, Haifei Shi
Mar 19, 2014·Molecular Metabolism·Jun Ho KimFranck Mauvais-Jarvis
Jun 3, 2015·Molecular and Cellular Endocrinology·Andrea L HevenerFranck Mauvais-Jarvis
Aug 31, 2013·Adipocyte·Esther Fuente-MartínJulie A Chowen
Apr 18, 2015·Journal of Diabetes Research·Anisha A GupteDale J Hamilton
Apr 4, 2015·Biochemistry Research International·Shady H TawfikMadiha H Helmy
May 28, 2013·Pathology, Research and Practice·Gulbanu ErkanSeren Ozenirler
Dec 3, 2014·Diabetes & Metabolism·N Chevalier, P Fénichel
Mar 20, 2013·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Carl LinnérYvonne Lundberg Giwercman

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.