Abstract
Machado-Joseph disease (MJD), an autosomal dominant spinocerebellar degeneration caused by an expanded CAG repeat on chromosome 14q32.1, is a disorder with wide range of neurological findings and brain regions involved. Studies evaluating neurophysiological parameters related to sensory gating in MJD are lacking. This study intends to investigate P50 suppression, an auditory mid-latency evoked potential in a test-conditioning paradigm, considered as an index of sensory gating function. Twelve patients with MJD, 24 normal subjects and 12 schizophrenic patients were evaluated. MJD subjects had higher P50 ratios as compared to normal subjects (76.2 vs. 42.1%, P = 0.001), but similar to the group of schizophrenic patients. The difference from controls was due to greater test amplitudes (3.4 vs. 2.0 microV, P = 0.002), rather than to conditioning amplitudes. Latencies were higher for the MJD subjects than for controls (60.4 vs. 56.1 ms, P = 0.016). MJD may present sensory gating dysfunction. However, the pattern of this dysfunction seems to slightly differ from that classically found in schizophrenia, were both test and conditioning amplitudes seem to be implicated. These results point out the P50 paradigm as a potential tool for fu...Continue Reading
References
Aug 1, 1976·Neurology·R N RosenbergP Shore
Jan 1, 1972·Neurology·K K NakanoA Spence
May 5, 1995·Neuroscience Letters·K M HershmanP C Bickford
Nov 1, 1994·Nature Genetics·Y KawaguchiI Akiguchi
Jul 1, 1993·Nature Genetics·Y TakiyamaS Ohta
Apr 1, 1996·Annals of Neurology·A DürrA Brice
Aug 1, 1997·Internal Medicine·M YamamotoG Sobue
Jan 27, 1998·Archives of Neurology·Y MurataS Nakamura
Jun 5, 1998·Schizophrenia Bulletin·L E AdlerR Freedman
Oct 6, 1999·Biological Psychiatry·G A LightD L Braff
Apr 28, 2000·The American Journal of Psychiatry·G A LightD L Braff
Jan 2, 2001·Acta Oto-laryngologica·H Takegoshi, T Murofushi
Aug 31, 2001·Archives of Neurology·E C EtchebehereE E Camargo
Jan 11, 2002·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·T FukutakeT Hattori
Oct 16, 2002·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Eduardo S GhisolfiDiogo R Lara
Citations
Mar 13, 2008·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Ming-Kuei LuChin-San Liu
May 20, 2008·Neuropsychologia·Torgeir MobergetRichard B Ivry
Sep 6, 2015·Brain and Language·Torgeir MobergetTor Endestad
Apr 22, 2015·PloS One·Tzu-Yun WangYu-Te Wu
Jul 15, 2011·Arquivos de neuro-psiquiatria·Jefferson BeckerJaderson Costa da Costa
Jun 13, 2019·Genetics and Molecular Biology·Gabriel Vasata FurtadoLaura Bannach Jardim
Apr 16, 2019·Genetics and Molecular Biology·Roberto GiuglianiFrancyne Kubaski
Apr 10, 2021·Journal of the Neurological Sciences·Meng-Ling ChenSheng-Han Kuo