PMID: 7034162Jan 1, 1981Paper

Impaired pancreatic innervation after selective gastric vagotomy. Reduction of the pancreatic polypeptide response to food and insulin hypoglycemia

Scandinavian Journal of Gastroenterology
N A LøvgrenT W Schwartz

Abstract

The secretion of pancreatic polypeptide (PP) was studied in 38 duodenal ulcer patients before, 4 months after, and, in 25 patients, again 18 months after either selective gastric vagotomy or parietal cell vagotomy. Selective gastric vagotomy on average reduced the PP response to food measured 4 months after operation to 20% of the preoperative value. The prolonged PP response (30-120 min) increased to 50% from the 4th to the 18th postoperative month (p less than 0.005). Parietal cell vagotomy did not significantly change the PP response to food, although in a few patients (3/15) the response was reduced to below one third of the preoperative value. The PP response to insulin hypoglycemia was measured after operation in 16 patients; those who had a reduced PP response to food demonstrated a response to hypoglycemia which was reduced to the same extent. It is concluded that PP secretion is generally unaffected by parietal cell vagotomy but is impaired after selective gastric vagotomy and that the prolonged PP response to food is partially regenerated after vagotomy. It is suggested that selective gastric vagotomy interferes with the vagal innervation of the PP-rich head of the pancreas.

References

Jan 22, 1977·Lancet·T E AdrianR C Russell
Mar 26, 1977·Lancet·T W Schwartz, J J Rehfeld
Mar 1, 1978·The Journal of Clinical Investigation·T W SchwartzF Stadil
Jan 1, 1978·Scandinavian Journal of Gastroenterology·L KayassehJ Girard
Dec 1, 1976·Gut·T E AdrianA J Barnes
Jul 1, 1980·Digestive Diseases and Sciences·I L Taylor
Jul 1, 1980·Digestive Diseases and Sciences·A I SternJ Waugh

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Citations

Jan 1, 1993·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·H KöhlerA Schafmayer
Feb 1, 1983·Journal of the Autonomic Nervous System·H R BerthoudB Jeanrenaud
Oct 1, 1983·Journal of the Autonomic Nervous System·P E DonahueL M Nyhus
Oct 1, 1983·Journal of the Autonomic Nervous System·T W Schwartz
Oct 1, 1983·Journal of the Autonomic Nervous System·J Louis-Sylvestre
Dec 1, 1987·Journal of the Autonomic Nervous System·L Rinaman, R R Miselis
Nov 1, 1986·Scandinavian Journal of Gastroenterology·P CantorJ F Rehfeld
Jan 1, 1989·American Journal of Surgery·F C BrunicardiD K Andersen
Apr 1, 1988·Scandinavian Journal of Gastroenterology·A SchafmayerH Köhler
Jun 17, 2006·Scandinavian Journal of Clinical and Laboratory Investigation·M B DamholtJ Hilsted
Feb 1, 1986·Journal of Endocrinological Investigation·S GambardellaG Menzinger
Dec 1, 1995·International Journal of Pancreatology : Official Journal of the International Association of Pancreatology·F C BrunicardiD K Andersen

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