Impaired pancreatic secretion in severely malnourished patients is a consequence of primary pancreatic dysfunction

Nutrition
Trevor A WinterS Bridger

Abstract

Severe undernutrition has been associated with reduced secretions of gastric acid and pancreatic enzymes. This may be the result of an impaired gut mucosal response to food and primary gastric parietal and pancreatic acinar cell secretory dysfunction as a consequence of the poor nutritional state. To investigate the relative contributions of these factors, severely undernourished patients underwent enteral-meal-stimulated (ES; n = 7) or intravenous hormone (pentagastrin and cholecystokinin-8)-stimulated (HS; n = 12) gastric acid and pancreatic enzyme secretion before and after a period of nutritional support. Results were evaluated in comparison with normal healthy control subjects (ES = 7, HS = 10). In the control subjects, enteral-meal and cholecystokinin-8 stimulation resulted in similar outputs of the pancreatic enzymes amylase (2213 versus 2305 U/h), lipase (84.93 versus 118.6 U/h), and trypsin (498.9 versus 341.4 U/h), whereas acid output was significantly lower in the ES group (10.90 versus 25.53 mEq/h; P < 0.01). Compared with controls, malnourished groups had significantly reduced secretions of amylase (ES = 870.1 U/h, HS = 686.5 U/h; P < 0.02), lipase (ES = 30.68 U/h, HS = 25.96 U/h; P < 0.02), and trypsin (ES = 175.6...Continue Reading

References

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Citations

Aug 17, 2006·Current Opinion in Clinical Nutrition and Metabolic Care·Trevor A Winter
Sep 7, 2006·Journal of Pediatric Gastroenterology and Nutrition·Sanda Nousia-ArvanitakisMichael Karamouzis
Dec 30, 2015·Critical Reviews in Food Science and Nutrition·David C DallasJ Bruce German
Feb 8, 2013·European Eating Disorders Review : the Journal of the Eating Disorders Association·Miguel Angel Martínez-OlmosFelipe F Casanueva
Jul 3, 2008·Digestion·D PohlUNKNOWN Kandahar Study Group
Jul 3, 2002·Experimental Biology and Medicine·Parimal ChowdhuryPhillip L Rayford
May 8, 2019·European Eating Disorders Review : the Journal of the Eating Disorders Association·Martha A Schalla, Andreas Stengel

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