PMID: 43554Jan 1, 1979

Impaired performance and sedation after a single dose of lorazepam

S E File, A Bond


In a double-blind cross-over study using normal student volunteers, the effects of 1 and 2.5 mg lorazepam on self-rated mood and bodily symptoms, as well as performance in a number of tests were assessed. Both doses significantly increased self ratings of physical and mental sedation, the effects being more marked 4 h after drug administration than after 1 h. Lorazepam impaired simple reaction time, verbal learning, number cancellation, symbol copying and performance in the digit-symbol substitution test. The impairments were greater with the 2.5 mg dose and were more marked 4 h after drug administration than after 1 h.


Jan 1, 1981·Psychopharmacology·S E File, T Silverstone
Jan 1, 1982·European Journal of Clinical Pharmacology·A Bond, M Lader
Jan 1, 1987·European Journal of Clinical Pharmacology·A PatatM Hucher
Jan 1, 1985·Neuroscience and Biobehavioral Reviews·R G Lister
Jan 1, 1984·Progress in Neuro-psychopharmacology & Biological Psychiatry·S E File
Apr 1, 1996·Environmental Health Perspectives·A Wetherell
Mar 1, 1991·Drug and Alcohol Dependence·K L PrestonG E Bigelow
Dec 1, 1983·British Journal of Clinical Pharmacology·S E File, R G Lister
Jul 1, 1985·British Journal of Clinical Pharmacology·A Patat, P Foulhoux
Sep 1, 1980·British Journal of Clinical Pharmacology·I Hindmarch
Aug 1, 1987·British Journal of Addiction·S D Ferrara
Jan 1, 1988·Psychological Medicine. Monograph Supplement·A HiggittM Lader


Feb 1, 1977·British Journal of Clinical Pharmacology·K A George, J W Dundee
Apr 15, 1978·Experientia·J BrownJ B Bowes
Jun 18, 1977·British Medical Journal·D C SkeggJ Perry
Nov 1, 1976·Anesthesiology·R L PizialiR J Moffat
May 1, 1971·Clinical Pharmacology and Therapeutics·H W ElliottW H Comer
Aug 1, 1970·British Journal of Anaesthesia·P R ClarkeJ A Thornton
Jan 1, 1982·European Journal of Clinical Pharmacology·A Bond, M Lader

Related Concepts

Reaction Time
Anti-Anxiety Effect
Verbal Learning
Sedative Effect
Mental Tests
Impaired Health

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