Impaired peroxisomal fat oxidation induces hepatic lipid accumulation and oxidative damage in Nile tilapia.

Fish Physiology and Biochemistry
Yan LiuZhen-Yu Du

Abstract

Many metabolic diseases in fish are often associated with lowered peroxisomal fatty acid (FA) β-oxidation. However, the physiological role of peroxisomal FA oxidation in lipid metabolism in fish still remains unclear. In the present study, a specific peroxisomal FA β-oxidation inhibitor, 10,12-tricosadiynoic acid (TDYA), was used to investigate the effects of impaired peroxisomal β-oxidation on growth performance, health status, and lipid metabolism in Nile tilapia. The results showed that the dietary TDYA treatment did not affect weight gain, but significantly decreased peroxisomal β-oxidation in the liver, and increased body fat accumulation. The fish with impaired peroxisomal β-oxidation exhibited higher contents of serum lipid and peroxidation products, and alanine aminotransferase activity, and significantly lowered hepatic activities of superoxide dismutase and catalase. The inhibited peroxisomal β-oxidation did not enhance mitochondrial β-oxidation activity, but compensatorily upregulated FA β-oxidation-related gene expression, and downregulated the gene expressions in lipolysis and lipogenesis. Taken together, TDYA treatment markedly induced lipid accumulation and hepatic oxidative damage via systemically depressing lip...Continue Reading

References

Mar 1, 1990·The American Journal of Physiology·C D MoyesP W Hochachka
Oct 11, 1983·Biochimica Et Biophysica Acta·J H VeerkampV W Van Hinsbergh
May 1, 1993·The American Journal of Physiology·E L Crockett, B D Sidell
Jan 16, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J CórdobaA T Blei
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Oct 21, 2005·Biochimica Et Biophysica Acta·Jia ZengDing Li
Oct 10, 2006·Biochimica Et Biophysica Acta·Yves PoirierJ Kalervo Hiltunen
Sep 8, 2007·Traffic·Jay I KoepkeStanley R Terlecky
Mar 28, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·W Ray KimUNKNOWN Public Policy Committee of the American Association for the Study of Liver Disease
Aug 30, 2008·Organic Letters·Jia ZengDing Li
Mar 3, 2010·Laboratory Investigation; a Journal of Technical Methods and Pathology·Aurore VluggensMustapha Cherkaoui-Malki
Oct 20, 2011·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jiansheng HuangJanardan K Reddy
Apr 27, 2012·Frontiers in Physiology·Paul A Walton, Michael Pizzitelli
May 9, 2012·Cell Metabolism·Deborah M Muoio, P Darrell Neufer
Aug 13, 2013·Biochimie·Marcus Nordgren, Marc Fransen
Mar 13, 2014·Journal of Inherited Metabolic Disease·Raymond Y WangJose E Abdenur
Jun 21, 2016·Biochimica Et Biophysica Acta·Li-Jun NingZhen-Yu Du
Jan 9, 2017·Trends in Endocrinology and Metabolism : TEM·Cynthia M Cipolla, Irfan J Lodhi
Aug 16, 2017·Oxidative Medicine and Cellular Longevity·Amparo Pascual-AhuirMarkus Proft
Oct 13, 2018·Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids·Q RaasS Savary
Jul 8, 2019·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Si-Lan HanZhen-Yu Du

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR
MDA
gene knockout

Software Mentioned

SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

FEMS Yeast Research
Barbara Knoblach, Richard A Rachubinski
Current Drug Metabolism
Mustapha Cherkaoui-MalkiPierre Andreoletti
Advances in Human Genetics
H W Moser
Ryōikibetsu shōkōgun shirīzu
Y Suzuki
Advances in Pediatrics
H W Moser
© 2021 Meta ULC. All rights reserved