PMID: 6983988Jan 1, 1982Paper

Impaired phagocytic function and increased immune complexes in diabetics with severe microangiopathy

Diabetes
M IavicoliD Andreani

Abstract

An increase in circulating immune complexes (AgAb) of medium size has been observed in diabetics with late complications. This increase may be related either to an increased formation or reduced clearance. Alternatively, both mechanisms may be involved. As medium-sized AgAb determined by the C1q solid phase method are mainly removed from circulation by the fixed phagocytes of the reticulo-endothelial system, we investigated the function of these cells using a colloid clearance test in diabetics with various degrees of microangiopathy. Microaggregated iodinated human serum albumin was injected into 30 diabetic volunteers with severe (group 1), moderate (group 2), and absent (group 3) microangiopathy, and into 40 normal volunteers. The colloid clearance was significantly reduced in diabetics with severe microangiopathy in comparison with patients who had no sign of microangiopathy, or with normal subjects. A significant correlation was found between reduced colloid clearance and increased levels of circulating AgAb determined by C1q solid phase method. Results of this study suggest that the increase in circulating AgAb observed in patients with severe microangiopathy may result from an impaired function of mixed phagocytes.

Citations

Mar 1, 1980·Diabetologia·D Andreani
Aug 1, 1980·Diabetologia·U Di MarioD Andreani
Dec 1, 1986·Diabetologia·P PozzilliD Andreani
Oct 1, 1982·Acta diabetologica latina·E R RichensM Hartog
May 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·J L WitztumA Kesaniemi
May 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·J L WitztumM Fisher
Jul 12, 2005·The Journal of Burn Care & Rehabilitation·David G Greenhalgh
Aug 19, 2011·Science Translational Medicine·Mark A Atkinson
Sep 2, 1978·Lancet·R ValcaviI Portioli
Jan 1, 1991·Clinical Immunology and Immunopathology·C K Abrass
Feb 1, 1987·Acta Paediatrica Japonica; Overseas Edition·B Weber
Jul 10, 2010·Clinical Science·Aron M Geurts, Carol Moreno
May 13, 1983·Science·S KoevaryR M Williams

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