Impaired postprandial apolipoprotein-B48 metabolism in the obese, insulin-resistant JCR:LA-cp rat: increased atherogenicity for the metabolic syndrome

Atherosclerosis
Donna F VineS D Proctor

Abstract

Postprandial lipaemia is a significant contributor to the development of dyslipidaemia and cardiovascular disease, which has more recently been shown as a potential risk factor for obesity and pre-diabetes. Clinically however, the diagnosis of early insulin-resistance remains confounded due to the fact that aberrations in lipid metabolism are not often readily identified using classic indicators of hypercholesterolemia (i.e. LDL). In this study, we assessed the metabolism of apolipoprotein-B48 (apoB48)-containing lipoproteins in an animal model of obesity and insulin-resistance, the JCR:LA-cp rat. The contribution of lipoproteins from the intestine was assessed by measuring plasma apoB48 concentration in the postprandial period following an oral fat load. Plasma apoB48 was measured by improved enhanced chemiluminescent detection and other biochemical parameters measured by established analysis. Fasting concentrations of plasma apoB48, postprandial apoB48 area under the curve (AUC), as well as incremental-AUC (iAUC), were all significantly greater in the obese phenotype compared to lean controls. Fasting apoB48 correlated significantly with apoB48-iAUC, triglyceride (TG)-iAUC and insulin-iAUC. In addition, there was a highly sig...Continue Reading

References

Jan 1, 1991·Comparative Biochemistry and Physiology. A, Comparative Physiology·G L LiuR N Redinger
Jan 16, 1990·Biochimica Et Biophysica Acta·P J DolphinJ C Russell
Nov 1, 1989·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·J C RussellP J Dolphin
Jun 2, 1987·Biochimica Et Biophysica Acta·P J DolphinJ C Russell
Aug 1, 1994·Current Opinion in Lipidology·J P Després, A Marette
Mar 1, 1994·Atherosclerosis·F KarpeA Hamsten
Feb 10, 1998·Diabetic Medicine : a Journal of the British Diabetic Association·C TaggartG H Tomkin
Nov 3, 1998·Journal of Internal Medicine·M C CabezasD W Erkelens
Oct 16, 1999·Arteriosclerosis, Thrombosis, and Vascular Biology·J S CohnJ Davignon
Apr 12, 2000·The Netherlands Journal of Medicine·M C Cabezas, D W Erkelens
Mar 10, 2001·Diabetes/metabolism Research and Reviews·G H Tomkin, D Owens
Aug 14, 2001·American Journal of Physiology. Endocrinology and Metabolism·J C MamoS Pal
Mar 14, 2002·Diabetes, Obesity & Metabolism·David N Brindley, James C Russell
Mar 16, 2002·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·L ManthaY Deshaies
Sep 28, 2002·Current Opinion in Lipidology·Spencer D ProctorJohn C L Mamo
Jun 14, 2003·Journal of the American College of Nutrition·Monique RomonJean Dallongeville
Jan 22, 2005·Annual Review of Medicine·David E Moller, Keith D Kaufman
Feb 25, 2005·Current Atherosclerosis Reports·ThB TwicklerJ S Cohn
Apr 20, 2005·Lancet·Robert H EckelPaul Z Zimmet
Dec 24, 2005·Revista española de cardiología·Paul ZimmetManuel Serrano Ríos

❮ Previous
Next ❯

Citations

Apr 29, 2010·Current Diabetes Reports·Byambaa EnkhmaaLars Berglund
Dec 3, 2008·International Journal of Obesity : Journal of the International Association for the Study of Obesity·M R RuthC J Field
May 8, 2008·Current Opinion in Lipidology·Khosrow Adeli, Gary F Lewis
Nov 14, 2013·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Emilie GrenierEmile Levy
Oct 26, 2011·Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre·Kazuhiko KotaniNobuyuki Taniguchi
Jul 6, 2012·Journal of Lipid Research·Ratnesh Kumar SinghMarica Bakovic
Aug 29, 2009·Journal of Atherosclerosis and Thrombosis·Makoto KinoshitaTamio Teramoto
May 17, 2007·Expert Opinion on Therapeutic Targets·Keith Suckling
Mar 11, 2008·Expert Review of Cardiovascular Therapy·Harold E BaysMichael H Davidson
Oct 18, 2011·Biochimica Et Biophysica Acta·Changting Xiao, Gary F Lewis
Oct 13, 2011·Biochimica Et Biophysica Acta·Xiaoyue Pan, M Mahmood Hussain
Aug 11, 2010·Free Radical Biology & Medicine·Michael J DuryeeGeoffrey M Thiele
Jun 21, 2015·The Journal of Nutritional Biochemistry·Robin P da SilvaRené L Jacobs
Aug 5, 2008·Atherosclerosis. Supplements·Hélène DuezGary F Lewis
Jul 26, 2008·Atherosclerosis. Supplements·Joanne HsiehKhosrow Adeli
Oct 10, 2009·British Journal of Pharmacology·J C RussellS D Proctor
Apr 30, 2014·The Journal of Nutritional Biochemistry·M Miriam Jacome-SosaSpencer D Proctor
Aug 2, 2016·Journal of Pediatric Gastroenterology and Nutrition·Inga C TellerPieter J J Sauer
Nov 13, 2014·Journal of Lipid Research·Emile Levy
Jan 11, 2014·Arteriosclerosis, Thrombosis, and Vascular Biology·Alain VeilleuxEmile Levy
Oct 31, 2008·Endocrine Reviews·Marc-Andre CornierRobert H Eckel
Apr 17, 2008·American Journal of Physiology. Endocrinology and Metabolism·James C RussellDavid N Brindley

❮ Previous
Next ❯

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.