Impaired prefrontal activity to regulate the intrinsic motivation-action link in schizophrenia

NeuroImage. Clinical
Kazuyoshi TakedaKazuyuki Nakagome

Abstract

A core feature of schizophrenia (SCZ) is impairment in intrinsic motivation. Although intrinsic motivation plays an important role in enhancing improvement of the social functioning, its neural mechanisms of impairment have yet to be clarified. We hypothesized that abnormal function of the frontostriatal loop consisting of the striatum and lateral prefrontal cortex (LPFC) may be related to impaired intrinsic motivation in SCZ. We tested this by comparing the brain activity measured by functional magnetic resonance imaging and behavioral parameters associated with movement, motivation, and cognitive control between 18 stable SCZ patients and 17 healthy control (HC) participants during a task that elicits intrinsic motivation. We also compared the functional connectivity during resting-state and the fractional anisotropy using diffusion tensor imaging analysis between the two groups. We adopted an enjoyable timing task to stop a stopwatch at an exact time, which in our previous study has demonstrated to elicit intrinsic motivation. Although the performance level in general was not different between groups, the SCZ group performed worse than the HC group in trials following "overshoot" errors (i.e., the response was too late). SCZ...Continue Reading

Citations

Jul 7, 2019·Psychiatry and Clinical Neurosciences·Yasuhiro MatsudaToshifumi Kishimoto
Dec 13, 2019·The Behavioral and Brain Sciences·Natsuki Ueda, Takashi Hanakawa
Mar 8, 2021·Schizophrenia Research·Brandon K AshinoffGuillermo Horga

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Software Mentioned

FNIRT
SPSS
plus
PASW Statistics
CONN
FSL
FMRIB Diffusion Toolbox
FLIRT
fslstats
Pickatlas

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