Impaired production of naive T lymphocytes in human T-cell leukemia virus type I-infected individuals: its implications in the immunodeficient state.

Blood
Yasunaga JiMasao Matsuoka

Abstract

Opportunistic infections frequently occur in patients with adult T-cell leukemia (ATL) and human T-cell leukemia virus type I (HTLV-I) carriers. However, the underlying mechanisms of such infections remain unknown. To clarify the mechanism of immunodeficiency in those infected with HTLV-I, this study analyzed the T-cell subsets in HTLV-I carriers and patients with HTLV-I-associated myelopathy/tropical spastic paraparesis and ATL using 3-color fluorescence with CD62L and CD45RA coexpression either with CD4(+) or CD8(+) T cells. The number of naive T lymphocytes was markedly suppressed in patients with ATL, particularly in those with acute form, compared with uninfected control individuals. The number of naive T cells was low in HTLV-I-infected individuals under 50 years old compared with uninfected individuals, whereas the number of memory T lymphocytes was greater in HTLV-I-infected individuals. Although the increase of memory T lymphocytes correlated with HTLV-I provirus loads, no relationship was found between naive T-cell counts and provirus loads. T-cell receptor rearrangement excision circles (TRECs), which are generated by DNA recombination during early T lymphopoiesis, were quantified to evaluate thymic function in HTLV-...Continue Reading

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Citations

Dec 23, 2003·International Journal of Hematology·Jun-ichirou Yasunaga, Masao Matsuoka
Sep 29, 2011·International Journal of Hematology·Junichiro Yasunaga, Masao Matsuoka
Oct 18, 2002·Trends in Molecular Medicine·Stuart P BerzinsRichard L Boyd
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Mar 27, 2007·Nature Reviews. Cancer·Masao Matsuoka, Kuan-Teh Jeang
Sep 13, 2005·Oncogene·Graham P Taylor, Masao Matsuoka
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Aug 9, 2011·Transplantation·Prashanth VallabhajosyulaDavid H Sachs
Nov 23, 2007·Journal of Gastroenterology and Hepatology·Tetsuo HirataJiro Fujita
Jun 28, 2003·Journal of Virology·Sallie R PermarDiane E Griffin
Nov 1, 2012·Journal of Biomedical Science·Sai-Wen TangChristine Neuveut
Feb 25, 2011·PLoS Pathogens·Yorifumi SatouMasao Matsuoka
Jul 27, 2006·International Journal of Hematology·Yasushi MatsubarTakashi Uchiyama
Sep 19, 2007·International Journal of Hematology·Yorifumi Satou, Masao Matsuoka
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Dec 23, 2015·Case Reports in Hematology·Toshiki TanakaShinsaku Imashuku
Mar 3, 2004·International Journal of Cancer. Journal International Du Cancer·Satoshi TakedaMasao Matsuoka

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