Impaired regulation of portal venous flow in response to a meal challenge as quantified by 4D flow MRI

Journal of Magnetic Resonance Imaging : JMRI
A Roldán-AlzateS B Reeder

Abstract

Portal and mesenteric hemodynamics is greatly altered in portal hypertension patients. This study utilizes 4D flow magnetic resonance imaging (MRI) to visualize and quantify changes in abdominal hemodynamics in patients with portal hypertension undergoing meal challenge. Twelve portal hypertension patients and six healthy subjects participated in the study. Baseline MRI was acquired after 5 hours of fasting. Postmeal MRI was obtained 20 minutes after subjects ingested EnSure Plus (574 mL). Imaging was performed at 3T using 4D flow MRI with an undersampled radial acquisition. Flow measurements were performed blinded to subject status (fasting/meal). Flow values for each vessel were compared before and after the meal challenge using paired Student's t-tests (P < 0.05). After meal challenge, significant increases in blood flow were observed in supraceliac aorta, portal vein, superior mesenteric vein, and artery in both groups (P < 0.05). In patients, hepatic artery (P = 0.001) and splenic vein (P = 0.045) flow decreased while azygos vein flow (P = 0.002) increased. Portal venous flow regulation to adjust the increasing mesenteric venous flow after a meal challenge may be impaired in patients with cirrhosis. The ability to comprehe...Continue Reading

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Citations

May 18, 2016·AJR. American Journal of Roentgenology·Alejandro Roldán-AlzateScott B Reeder
May 20, 2016·European Radiology·Keyur ParekhCynthia K Rigsby
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Sep 15, 2020·Abdominal Radiology·Paul KennedyBachir Taouli
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May 4, 2017·AJR. American Journal of Roentgenology·Eric J KellerJeremy D Collins
Aug 11, 2018·Computer Methods in Biomechanics and Biomedical Engineering. Imaging & Visualization·David R RutkowskiAlejandro Roldán-Alzate
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Oct 12, 2021·Frontiers in Physiology·Seyed M SeyedpourTim Ricken

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