Abstract
Involvement of both the serotonergic and the endogenous opioid systems in the onset of depressive behavior has been suggested. Previously we showed that serotonin (5-hydroxytryptamine) facilitates beta-endorphin release in the nucleus accumbens (NAcc). Herein, the microdialysis method was used to assess in vivo the effects of serotonin on beta-endorphin release in a rat model of depressive behavior (the Flinders sensitive line, FSL), before and after antidepressant treatment. The basal extracellular level of beta-endorphin in the NAcc of FSL rats did not differ significantly from that in control rats. However, serotonin-induced beta-endorphin release was impaired in FSL rats. Chronic treatment (18 days) with desipramine or paroxetine did not significantly affect the extracellular levels of beta-endorphin in the NAcc of either the FSL or control rats. However, the chronic antidepressant treatment did normalize the serotonin-induced release of beta-endorphin in FSL rats, as well as their behavioral manifestation of depressive behavior. Our results show that depressive behavior may relate to an impaired effect of serotonin on beta-endorphin release in the NAcc in a rat model of depression, and suggest a possible new mode of action...Continue Reading
References
Dec 1, 1979·Pain·N G WardR O Friedel
Dec 1, 1993·Journal of Affective Disorders·G M GoodwinH Dick
Jan 1, 1993·Neuroscience and Biobehavioral Reviews·D H Overstreet
Apr 1, 1996·Current Opinion in Neurobiology·R A Wise
Apr 10, 1999·Brain Research·A ZangenG Yadid
Citations
Mar 22, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Andras Bilkei-GorzoAndreas Zimmer
Nov 13, 2003·Peptides·Richard J Bodnar, Maria M Hadjimarkou
Feb 16, 2010·Brain Research·F MatriscianoF Nicoletti
Aug 4, 2009·Neuropeptides·K M HegadorenN Lacaze-Masmonteil
Aug 30, 2008·Progress in Neuro-psychopharmacology & Biological Psychiatry·Ricard NavinésCristòbal Gastó
Jul 2, 2008·Neuropharmacology·F MatriscianoF Nicoletti
May 5, 2004·Experimental Physiology·T PriorP K Rangachari
Mar 9, 2006·Pharmacology & Therapeutics·Mark J Millan
Jun 1, 2005·Neuroscience and Biobehavioral Reviews·David H OverstreetGal Yadid
Jun 20, 2008·Proceedings of the National Academy of Sciences of the United States of America·Dipak K SarkarJason Marano
Sep 29, 2009·Archives of Pharmacal Research·Ozgür Devrim CanYusuf Oztürk
Sep 29, 2019·Journal of Prevention & Intervention in the Community·Julian A Dedeaux, Rhonda K Lewis
Dec 1, 2005·Human Nature : an Interdisciplinary Biosocial Perspective·Candace S Alcorta, Richard Sosis
Mar 13, 2020·Frontiers in Psychology·Michael Kirsch, Michael B Buchholz
Aug 13, 2011·Cancer Research·Dipak K SarkarSepide Mojtehedzadeh
Jul 3, 2021·Animals : an Open Access Journal From MDPI·Yeonju Choi, Minjung Yoon