Impaired renal function before kidney procurement has a deleterious impact on allograft survival in very old deceased kidney donors.

Scientific Reports
Mehdi MaanaouiMarc Hazzan

Abstract

As the use of elderly kidney donors for transplantation is increasing with time, there is a need to understand which factors impact on their prognosis. No data exist on the impact of an impaired renal function (IRF) in such population. 116 kidney recipients from deceased kidney donors over 70 years were included from 2005 to 2015 in a single-center retrospective study. IRF before organ procurement was defined as a serum creatinine above 1.0 mg/dl or a transient episode of oligo-anuria. Mean ages for donors and recipients were respectively 74.8 ± 3.5 and 66.7 ± 8.0. Graft survival censored for death at 5 years was of 77%. Using a multivariate analysis by Cox model, the only predictor of graft loss present in the donor was IRF before organ procurement (HR 4.2 CI95[1.8-9.7]). IRF was also associated with significant lower estimated glomerular filtration rates up to 1 year post-transplantation. By contrast, KDPI score (median of 98 [96-100]), was not associated with the risk of graft failure. Then, IRF before kidney procurement may define a risk subgroup among very-old deceased kidney donors, in whom pre-implantatory biopsies, dual kidney transplantation or calcineurin inhibitor-free immunosuppressive regimen could help to improve ...Continue Reading

References

Dec 10, 1999·Journal of the American Society of Nephrology : JASN·G RemuzziB M Brenner
Apr 16, 2003·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Robert A MetzgerRobert M Merion
Feb 20, 2008·Transplant International : Official Journal of the European Society for Organ Transplantation·Markus GubaHelmut Arbogast
Jun 23, 2009·Transplantation·Andrea ColliniMario Carmellini
Sep 1, 2009·Transplantation Proceedings·E GavelaJ F Crespo
May 7, 2011·Transplantation·Anja GallinatGeorgios C Sotiropoulos
Apr 5, 2013·Transplant International : Official Journal of the European Society for Organ Transplantation·Anja GallinatJürgen Treckmann
Apr 30, 2013·Transplantation Proceedings·L MarconiA Mota
Jan 30, 2014·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·B TanrioverM A Hardy
Mar 22, 2014·Transplantation·Bendix R SlegtenhorstStefan G Tullius
Aug 21, 2014·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A B MassieD L Segev
Aug 27, 2014·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·I GandolfiniU Maggiore
Oct 6, 2014·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Alison P K Lee, Daniel Abramowicz
Oct 29, 2015·Transplant International : Official Journal of the European Society for Organ Transplantation·Amaia SagastaManel Solé
Oct 30, 2016·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·S FlormanC P Larsen
Dec 21, 2016·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·K A NewellA Chandraker
Aug 10, 2017·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Piero RuggenentiPaolo Rigotti
Apr 5, 2018·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Lukas Johannes LehnerOliver Staeck
May 17, 2018·The New England Journal of Medicine·Stefan G Tullius, Hamid Rabb
Jun 10, 2018·Nefrología : publicación oficial de la Sociedad Española Nefrologia·Carlos Arias-CabralesJulio Pascual
Sep 24, 2018·Nefrología : publicación oficial de la Sociedad Española Nefrologia·Jorge Calvillo-ArbizuLaura M Roa-Romero
Nov 25, 2018·Kidney International·Isaac E HallChirag R Parikh

❮ Previous
Next ❯

Software Mentioned

BENEFIT
R
EXT
R Development Core Team

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.