PMID: 9170009May 1, 1997Paper

Impaired renal haemodynamic response to amino acid infusion in essential hypertension during angiotensin converting enzyme inhibitor treatment

Journal of Hypertension
I N TietzeE B Pedersen

Abstract

To determine whether hyperfiltration induced by amino acid infusion can be influenced by angiotensin converting enzyme (ACE) inhibition. We studied the acute effects of ramipril in 12 healthy control subjects and in 14 patients with essential hypertension. We studied also the effects of 2 months' treatment with ramipril inn 12 patients with essential hypertension and performed a time-control study without amino acids infusion with 12 control subjects. The glomerular filtration rate (GFR), renal plasma flow (RPF), fractional excretion of sodium (FENa) and fractional excretion of lithium (FELi) were determined during 6 clearance periods of 30 min each and amino acids infusion was administered during the last four periods. Plasma concentrations of angiotensin II, aldosterone, atrial natriuretic peptide (ANP), arginine vasopressin, insulin and glucagon were determined. Both the GFR and the RPF increased markedly in healthy subjects after amino acid infusion both with (GFR 7%, RPF 7%) and without ramipril (GFR 7%), RPF 8%), both P < 0.05. Ramipril administered acutely to essential hypertensives prevented the amino acid-induced increase in RPF [with ramipril 5% (NS), without ramipril 9% (P < 0.05)]. The GFR increased equally with (5%...Continue Reading

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Citations

May 16, 2002·Clinical and Experimental Pharmacology & Physiology·Klaus ThomsenAllan Flyvbjerg
May 12, 2009·The Medical Clinics of North America·Nitin KhoslaGeorge L Bakris
May 28, 2004·Pharmacotherapy·Benjamin J Epstein
Feb 2, 2017·Journal of the American Society of Nephrology : JASN·Lennart TonneijckJaap A Joles
Aug 22, 2021·Clinical Physiology and Functional Imaging·Ann Mai ØstergaardJune A Ejlersen

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