Abstract
We previously have shown that Dahl salt-sensitive rats increase renal vascular resistance in response to excessive salt feeding before total peripheral resistance increases and hypertension occurs. Failure of renal vasculature to dilate, as normally occurs in Dahl salt-resistant rats fed a high salt diet, may play a role in the development of hypertension in Dahl salt-sensitive rats. We also showed that renal vasculature in salt-sensitive rats is hyperreactive to vasoconstrictors and hyporeactive to vasodilators. Atrial natriuretic peptide, by stimulating cell-bound receptors, and nitroprusside, by generating nitric oxide, cause renal vasodilation by generating cGMP. Studies were undertaken to determine whether defective renal vasodilation in Dahl salt-sensitive rats is due to impaired production of cGMP. We examined the influence of nitroprusside infusion and salt intake on renal vascular resistance and cGMP excretion in salt-sensitive rats. Results demonstrate that salt feeding and nitroprusside infusion increase cGMP excretion and decrease renal vascular resistance in salt-resistant rats (P < .01), and, although this relationship was less clear in salt-sensitive rats, there was a reciprocal relationship between renal vascula...Continue Reading
References
Oct 1, 1992·Hypertension·S SimchonJ Brensilver
Nov 1, 1991·The Journal of Clinical Investigation·P Y Chen, P W Sanders
Jun 1, 1991·Hypertension·S SimchonT W Brown
Jun 1, 1989·Hypertension·S SimchonS Chien
Jul 1, 1986·The Journal of Clinical Investigation·F Murad
Oct 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·C L HuangM G Cogan
Jun 1, 1987·Hypertension·T F LüscherL Raij
Feb 1, 1987·Hypertension·T F LüscherP M Vanhoutte
Jan 1, 1968·Circulation Research·L K DahlG J Leitl
Aug 27, 1981·European Journal of Pharmacology·B Garthoff, S Kazda
May 1, 1995·The Journal of Clinical Investigation·A Y Deng, J P Rapp
Feb 1, 1993·The Journal of Clinical Investigation·P J Shultz, J P Tolins
Jun 1, 1962·The Journal of Experimental Medicine·L K DAHLL TASSINARI
Citations
Sep 2, 2000·European Journal of Pharmacology·K JackeB Lemmer
Jan 7, 1999·Physiology & Behavior·M A BayorhV M Chenault
Dec 5, 2009·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Geraldine DaumerieMildred A Pointer
Nov 24, 1999·Clinical and Experimental Pharmacology & Physiology·A KasuyaS Satoh
Jun 27, 2003·Journal of Cardiovascular Pharmacology·Patrick FordeMaría R Trolliet
Jul 11, 2003·Cardiology in Review·John KanellisRichard J Johnson
Jun 9, 2011·Acta Physiologica·N W Rajapakse, D L Mattson
Sep 9, 2011·American Journal of Physiology. Renal Physiology·Gustavo R AresPablo A Ortiz
Sep 18, 1997·The Journal of Clinical Investigation·G GuptaR S Danziger
Jan 5, 2002·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Y HigashiT Oshima
Apr 25, 2000·Biochemical and Biophysical Research Communications·S Behrends, K Vehse
Mar 22, 2000·Journal of Hypertension·R S DanzigerM F Leppert
Mar 31, 2009·Journal of Hypertension·William M MangerFrancis J Haddy
Dec 10, 2003·British Journal of Pharmacology·Sheila M GardinerTerence Bennett
Jan 2, 2015·American Journal of Hypertension·Mildred A PointerCandace Wells
May 3, 2008·American Journal of Hypertension·Shaleka L EleyMildred A Pointer
Feb 21, 2009·American Journal of Hypertension·Alexei Y BagrovOlga V Fedorova
Dec 31, 2015·PloS One·Linda S HoffmannJohannes-Peter Stasch
Oct 23, 1997·Hypertension·F M KarlsenN H Holstein-Rathlou
Dec 1, 2001·Clinical and Experimental Hypertension : CHE·L S Tallam, B S Jandhyala
May 8, 2001·Clinical and Experimental Hypertension : CHE·M A BayorhM Thierry-Palmer
Jun 19, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Mátyás SzentiványiAllen W Cowley
Mar 5, 2002·Journal of Hypertension·Francesco CosentinoThomas F Lüscher
Aug 13, 1999·The American Journal of Physiology·M A RuddJ Loscalzo
Aug 1, 2012·Physiological Research·J ZichaJ Kuneš
Sep 18, 1997·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·B C Kone