Impaired resistance to the development of toxoplasmic encephalitis in interleukin-6-deficient mice.

Infection and Immunity
Y SuzukiJ S Remington

Abstract

The role of interleukin-6 (IL-6) in the pathogenesis of toxoplasmic encephalitis (TE) was examined by using IL-6-targeted mutant (IL-6(-/-)) mice. At 4 and 8 weeks after infection with the ME49 strain of Toxoplasma gondii, significantly greater numbers of T. gondii cysts and areas of inflammation associated with tachyzoites were observed in brains of IL-6(-/-) mice than in those of control mice. Large areas of necrosis were observed only in brains of IL-6(-/-) mice. Tachyzoites were frequently detected in the areas of necrosis, suggesting that necrosis was caused by proliferation of the parasite. These results indicate that IL-6 is protective against development of TE by preventing formation of T. gondii cysts and proliferation of tachyzoites in brains of infected mice. Whereas in brains of control mice, large numbers of inflammatory cells were always observed in areas where tachyzoites were detected, in brains of IL-6(-/-) mice, only small numbers of inflammatory cells were observed in many areas with tachyzoites. Lymphocyte preparations isolated from brains of infected control mice had significantly higher ratios of gamma/delta T cells and CD4+ alpha/beta T cells but lower ratios of CD8+ alpha/beta T cells compared to those o...Continue Reading

References

Dec 1, 1979·The Journal of Infectious Diseases·C B Wilson, J S Remington
Aug 1, 1992·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·B J Luft, J S Remington
Sep 1, 1995·Annals of Neurology·R M ElfontG W Goldstein
Jan 1, 1993·Advances in Immunology·S AkiraT Kishimoto

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Citations

Jan 27, 2000·Medical Mycology·F H van EnckevortB J Kullberg
Jun 10, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Alejandro V VillarinoChristopher A Hunter
Jan 20, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sara T PassosChristopher A Hunter
Oct 19, 2011·Expert Reviews in Molecular Medicine·Yasuhiro SuzukiEri Ochiai
May 25, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jonathan S SilverChristopher A Hunter
Sep 1, 2012·The Pediatric Infectious Disease Journal·Carlos Henryque de Souza-e-SilvaRicardo Wagner de Almeida Vitor
Dec 18, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Judith HogeHans-Willi Mittrücker
Feb 20, 2019·Neurochemical Research·Tatyana Shulyatnikova, Alexei Verkhratsky
Feb 29, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·H KangY Suzuki
Feb 28, 2002·The Journal of Infectious Diseases·Yasuhiro Suzuki
Apr 19, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hoil KangYasuhiro Suzuki
Apr 9, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Irina RochmanS Z Ben-Sasson
Feb 13, 2007·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Marcel Batten, Nico Ghilardi
Jul 9, 2010·Journal of Leukocyte Biology·J S Silver, C A Hunter
Mar 5, 2008·The Journal of Parasitology·Eréndira Estrada-VillaseñorPedro Ostoa-Saloma
Mar 31, 2012·Virulence·Sabrina M FeustelOliver Liesenfeld
Sep 8, 2012·Seminars in Immunopathology·Christopher D DupontChristopher A Hunter
Jan 23, 2013·Acta Ophthalmologica·Cynthia A CordeiroAntônio L Teixeira
Feb 21, 2013·Translational Psychiatry·R M GardnerH Karlsson
Nov 9, 2002·The Journal of Infectious Diseases·Yasuhiro Suzuki
Jul 4, 1998·Parasite Immunology·H JebbariJ Alexander
May 5, 2007·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Xisheng WangYasuhiro Suzuki
Dec 22, 2005·Clinical and Experimental Immunology·B RoseS Martin
Nov 14, 2006·Parasite Immunology·L A JonesC W Roberts
Feb 9, 2012·Current Protocols in Immunology·Carlos Subauste
Sep 3, 2010·Nature Reviews. Drug Discovery·Manfred KopfBenjamin J Marsland
Apr 12, 2012·Journal of Leukocyte Biology·David B ChouYasmine Belkaid
Jun 2, 2011·Infection and Immunity·Isabel Dellacasa-LindbergAntonio Barragan
Oct 21, 2016·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Egle Cekanaviciute, Marion S Buckwalter
Aug 8, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Katrin DrögemüllerDirk Schlüter
Apr 24, 2012·The Journal of Reproduction and Development·Xing-Hui ShenNam-Hyung Kim
Jul 7, 2005·Nature Reviews. Immunology·Christopher A Hunter
Jun 17, 2005·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Xisheng WangYasuhiro Suzuki

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