Impaired Response Selection During Stepping Predicts Falls in Older People-A Cohort Study

Journal of the American Medical Directors Association
Daniel SchoeneStephen R Lord

Abstract

Response inhibition, an important executive function, has been identified as a risk factor for falls in older people. This study investigated whether step tests that include different levels of response inhibition differ in their ability to predict falls and whether such associations are mediated by measures of attention, speed, and/or balance. A cohort study with a 12-month follow-up was conducted in community-dwelling older people without major cognitive and mobility impairments. Participants underwent 3 step tests: (1) choice stepping reaction time (CSRT) requiring rapid decision making and step initiation; (2) inhibitory choice stepping reaction time (iCSRT) requiring additional response inhibition and response-selection (go/no-go); and (3) a Stroop Stepping Test (SST) under congruent and incongruent conditions requiring conflict resolution. Participants also completed tests of processing speed, balance, and attention as potential mediators. Ninety-three of the 212 participants (44%) fell in the follow-up period. Of the step tests, only components of the iCSRT task predicted falls in this time with the relative risk per standard deviation for the reaction time (iCSRT-RT) = 1.23 (95%CI = 1.10-1.37). Multiple mediation analys...Continue Reading

Associated Clinical Trials

Citations

Jun 26, 2018·The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences·Liis UigaRich S W Masters
May 11, 2019·The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences·Justine MagnardThibault Deschamps
May 20, 2020·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Daniel Boari CoelhoAndrea C de Lima-Pardini
Jun 1, 2018·Annals of Geriatric Medicine and Research·Miji KimChang Won Won
Oct 3, 2020·European Review of Aging and Physical Activity : Official Journal of the European Group for Research Into Elderly and Physical Activity·Klaus HauerChristian Werner
Nov 28, 2019·Aging Clinical and Experimental Research·Antonino CatalanoNunziata Morabito
Jul 3, 2019·Frontiers in Aging Neuroscience·Frederico Pieruccini-FariaDaniel Schoene
Apr 4, 2021·Brain Sciences·Sara A HarperDavid A E Bolton
Nov 13, 2020·Neurophysiologie clinique = Clinical neurophysiology·Madli BayotArnaud Delval
Nov 8, 2018·Dementia and Geriatric Cognitive Disorders·Mark S RedfernJ Richard Jennings

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.