PMID: 8584357Nov 1, 1995Paper

Impaired response to hepatitis B vaccine in children receiving anticancer chemotherapy

The Pediatric Infectious Disease Journal
L HoviU M Saarinen

Abstract

Serologic responses to hepatitis B vaccine were investigated in 197 pediatric cancer patients. The patients, ages 1 to 21 years, comprised 66 with solid tumors, 101 with hematologic malignancies and 30 with various benign conditions. Of them 51 were receiving cytotoxic chemotherapy and 114 had not received chemotherapy for 0.2 to 11 years. Three doses of plasma-derived hepatitis B vaccine (20 micrograms) were given at 0, 1 and 6 months; and antibody concentrations to hepatitis B surface antigen were determined at 3, 6 and 8 months. The geometric mean antibody concentration after 3 vaccine doses was 1076 mIU/ml in cancer patients receiving chemotherapy and 18,833 mIU/ml in cancer patients not receiving chemotherapy. The protective titer of antibody (> or = 10 mIU/ml) was reached after 3 doses of vaccine by 67% of patients receiving chemotherapy and by 97% of those not receiving chemotherapy. The patients being treated for solid tumors had weaker responses than those being treated for hematologic malignancies: after 3 vaccine doses no response was observed in 6 of 11 patients with solid tumors compared with 3 of 25 of patients with hematologic malignancies. Children receiving anticancer chemotherapy have essentially weaker respon...Continue Reading

Citations

May 21, 1998·Leukemia Research·S GoyalS H Advani
May 29, 2014·BioMed Research International·Simone CesaroDésirée Caselli
Oct 7, 2006·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Abigail L SommerJudith A Smith
Aug 31, 2011·The American Journal of Gastroenterology·Jonathan MosesChristine Carter-Kent
Mar 17, 2007·Pediatric Blood & Cancer·Joyce W YuBruce D Mazer
Nov 8, 2001·Journal of the American Veterinary Medical Association·C J HenryM L Higginbotham
Aug 25, 2015·Revista chilena de pediatría·Rodolfo VillenaMaría Elena Santolaya
Jun 26, 2018·MMWR. Recommendations and Reports : Morbidity and Mortality Weekly Report. Recommendations and Reports·Sarah SchillieNoele P Nelson
Oct 21, 1998·Revista de saúde pública·L F Bricks
Jul 6, 2000·Medical and Pediatric Oncology·A MeralU Günay
Aug 10, 2020·Journal of Pediatric Hematology/oncology·Manal H El-SayedIman I Salama
Jul 29, 2021·World Journal of Gastrointestinal Pharmacology and Therapeutics·Niraj James ShahKumar Pallav

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