Impaired retinal microcirculation in multiple sclerosis

Multiple Sclerosis : Clinical and Laboratory Research
Hong JiangJianhua Wang

Abstract

The transparent ocular structure enables quantitative analysis of microvasculature of retina, a neuronal tissue affected by multiple sclerosis (MS). The aim of this study was to determine whether the retinal blood flow velocity and flow volume at the macula are impaired in patients with relapsing remitting multiple sclerosis (RRMS). A total of 17 RRMS patients and 17 age- and gender-matched healthy subjects were assessed. A retinal function imager was used to measure the blood flow velocity of retinal arterioles and venules and to calculate the total perifoveal blood flow volume. The blood flow velocities of the retinal arterioles (3.34 ± 0.89 mm/s) and venules (2.61 ± 0.6 mm/s) were significantly lower in MS patients than normal subjects (arteriole: 4.10 ± 0.87 mm/s; venule: 3.22 ± 0.65 mm/s, both p = 0.01). In addition, the total perifoveal blood flow volume in arterioles (3.74 ± 1.64 nL/s) and venules (3.81 ± 1.60 nL/s) were significantly lower in MS patients than in normal subjects (arteriole: 4.87 ± 1.41 nL/s, p = 0.02; venule: 4.71 ± 1.64 nL/s, p = 0.04). The impaired retinal microcirculation in RRMS patients indicates microvascular dysfunction in MS.

References

Sep 28, 2000·The New England Journal of Medicine·J H NoseworthyB G Weinshenker
Apr 3, 2002·Annals of Internal Medicine·Seamus P WheltonJiang He
Oct 19, 2005·Brain : a Journal of Neurology·Alexandra KutzelniggHans Lassmann
May 12, 2006·Neurological Research·Alireza MinagarJ Steven Alexander
Aug 23, 2006·Clinical and Experimental Pharmacology & Physiology·Ian B Puddey, Lawrence J Beilin
May 2, 2007·Neurology·Jorge SepulcrePablo Villoslada
May 3, 2007·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Matilde IngleseRobert I Grossman
May 31, 2008·BMB Reports·Yoon Kyung Choi, Kyu-Won Kim
Apr 3, 2009·Brain : a Journal of Neurology·Josa M FrischerHans Lassmann
Apr 23, 2009·Klinische Monatsblätter für Augenheilkunde·A KochkorovS Orgül
Mar 31, 2011·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Christopher M HollandCharles R G Guttmann
Jun 11, 2011·Journal of Neurology·David PalingDavid Miller
Mar 1, 2012·Neurology·Nieraj Jain, M Tariq Bhatti
Feb 23, 2013·Multiple Sclerosis : Clinical and Laboratory Research·Christel SteenJacques De Keyser
May 24, 2013·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Jay ChhablaniWilliam R Freeman
Aug 2, 2013·Neurology·Santiago Ortiz-PérezPablo Villoslada
Sep 21, 2013·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·David PalingXavier Golay
May 17, 2014·The British Journal of Ophthalmology·Xiaogang WangDavid Huang

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Citations

Jun 17, 2016·The EPMA Journal·Katarzyna KonieczkaJuerg Kesselring
Nov 8, 2016·American Journal of Ophthalmology·Min LiJianhua Wang
May 3, 2019·Current Eye Research·Yi LiuJianhua Wang
Dec 8, 2016·American Journal of Physiology. Heart and Circulatory Physiology·Delia Cabrera DeBucAkos Koller
Sep 19, 2019·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·W A J BirkhoffA F Cohen
Feb 21, 2019·Investigative Ophthalmology & Visual Science·Ying LinJianhua Wang
Feb 13, 2020·Neurological Research·Mahmut Oğuz UlusoySelen Işık-Ulusoy
Mar 13, 2020·Brain : a Journal of Neurology·Iris KleerekooperS Anand Trip
Jan 9, 2018·Current Eye Research·Liang WangJianhua Wang
Aug 25, 2018·Eye and Vision·Giovana Rosa GameiroJianhua Wang
Apr 18, 2019·Eye and Vision·Ce ShiJianhua Wang
Jan 19, 2021·Progress in Retinal and Eye Research·Amir H KashaniJohn M Ringman
Feb 2, 2021·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Marie GuerratyArvind P Pathak
May 20, 2021·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Brian Mac GroryWuwei Feng
Aug 11, 2020·American Journal of Ophthalmology·Ga Eun NamSu Jeong Song
Sep 26, 2017·Microvascular Research·W BirkhoffJ Burggraaf

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Software Mentioned

STATISTICA
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