Impaired right ventricular hemodynamics indicate preclinical pulmonary hypertension in patients with metabolic syndrome

Journal of the American Heart Association
Deepa M GopalJennifer E Ho

Abstract

Metabolic disease can lead to intrinsic pulmonary hypertension in experimental models. The contributions of metabolic syndrome (MetS) and obesity to pulmonary hypertension and right ventricular dysfunction in humans remain unclear. We investigated the association of MetS and obesity with right ventricular structure and function in patients without cardiovascular disease. A total of 156 patients with MetS (mean age 44 years, 71% women, mean body mass index 40 kg/m(2)), 45 similarly obese persons without MetS, and 45 nonobese controls underwent echocardiography, including pulsed wave Doppler measurement of pulmonary artery acceleration time (PAAT) and ejection time. Pulmonary artery systolic pressure was estimated from PAAT using validated equations. MetS was associated with lower tricuspid valve e' (right ventricular diastolic function parameter), shorter PAAT, shorter ejection time, and larger pulmonary artery diameter compared with controls (P<0.05 for all). Estimated pulmonary artery systolic pressure based on PAAT was 42±12 mm Hg in participants with MetS compared with 32±9 and 32±10 mm Hg in obese and nonobese controls (P for ANOVA <0.0001). After adjustment for age, sex, hypertension, diabetes, body mass index, and triglyc...Continue Reading

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Citations

Feb 23, 2020·Journal of the American Heart Association·Rachel C FrankJennifer E Ho
Feb 4, 2016·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·M S BianchimV Z Dourado
Apr 21, 2016·Expert Review of Cardiovascular Therapy·Norbert F VoelkelMark R Nicolls
Sep 30, 2016·Pulmonary Circulation·Salil SharmaMansoureh Eghbali
Sep 4, 2020·World Journal of Cardiology·Manouchkathe CassagnolAmgad N Makaryus
Aug 7, 2018·The Journal of Clinical Investigation·Miranda K Culley, Stephen Y Chan
Apr 6, 2021·European Journal of Radiology·Kai LinJames C Carr
Apr 28, 2021·The Journal of Clinical Investigation·Miranda K CulleyStephen Y Chan

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Software Mentioned

PAAT
Stata

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