Impaired Right Ventricular Mechanics at Rest and During Exercise Are Associated With Exercise Capacity in Patients With Hypertrophic Cardiomyopathy

Journal of the American Heart Association
Xiao-Peng WuXiu-Zhang Lu

Abstract

Background Impaired right ventricular ( RV ) function indicates RV involvement in patients with hypertrophic cardiomyopathy ( HCM ). We aimed to assess RV function at rest and during exercise in HCM patients and to examine the association between impaired RV mechanics and exercise capacity. Methods and Results A total of 76 HCM patients (48 without and 28 with RV hypertrophy) and 30 age- and sex-matched controls were prospectively recruited. RV function was evaluated at rest and during semisupine bicycle exercise by conventional echocardiography and 2-dimensional speckle-tracking imaging. Exercise capacity was measured by metabolic equivalents. RV functional reserve was calculated as the difference of functional parameters between peak exercise and rest. Compared with controls, HCM patients had significantly higher RV free wall thickness, lower RV global longitudinal strain and RV free wall longitudinal strain at rest and during exercise, and reduced RV systolic functional reserve. Compared with those with HCM without RV hypertrophy, patients with HCM with RV hypertrophy had lower metabolic equivalents. Among HCM patients, an effective correlation was seen between exercise capacity and peak exercise RV global longitudinal strai...Continue Reading

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Citations

Feb 11, 2020·Heart Failure Reviews·Ioana Danuta Muresan, Lucia Agoston-Coldea
Jun 3, 2021·Journal of Clinical Medicine·Adrián Bayonas-RuizBárbara Bonacasa
Mar 25, 2021·Scandinavian Cardiovascular Journal : SCJ·Simon Girmai BergerMathis Korseberg Stokke
Oct 17, 2020·Trends in Cardiovascular Medicine·Luna CavigliFlavio D'Ascenzi

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Methods Mentioned

BETA
coronary artery bypass

Software Mentioned

MedCalc
exe
RVGLS
STI
SPSS
QLAB

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