Impaired S-nitrosylation of the ryanodine receptor caused by xanthine oxidase activity contributes to calcium leak in heart failure.

The Journal of Biological Chemistry
Daniel R GonzalezJoshua M Hare

Abstract

S-Nitrosylation is a ubiquitous post-translational modification that regulates diverse biologic processes. In skeletal muscle, hypernitrosylation of the ryanodine receptor (RyR) causes sarcoplasmic reticulum (SR) calcium leak, but whether abnormalities of cardiac RyR nitrosylation contribute to dysfunction of cardiac excitation-contraction coupling remains controversial. In this study, we tested the hypothesis that cardiac RyR2 is hyponitrosylated in heart failure, because of nitroso-redox imbalance. We evaluated excitation-contraction coupling and nitroso-redox balance in spontaneously hypertensive heart failure rats with dilated cardiomyopathy and age-matched Wistar-Kyoto rats. Spontaneously hypertensive heart failure myocytes were characterized by depressed contractility, increased diastolic Ca(2+) leak, hyponitrosylation of RyR2, and enhanced xanthine oxidase derived superoxide. Global S-nitrosylation was decreased in failing hearts compared with nonfailing. Xanthine oxidase inhibition restored global and RyR2 nitrosylation and reversed the diastolic SR Ca(2+) leak, improving Ca(2+) handling and contractility. Together these findings demonstrate that nitroso-redox imbalance causes RyR2 oxidation, hyponitrosylation, and SR C...Continue Reading

References

Jan 1, 1997·Cell Calcium·D StoyanovskyG Salama
Apr 16, 1998·The Journal of Biological Chemistry·S AleryaniP Kostka
Mar 26, 1998·Biochemical and Biophysical Research Communications·D Jourd'heuilM B Grisham
May 9, 1998·The Journal of Biological Chemistry·M TrujilloR Radi
Jun 17, 1998·Biochemical and Biophysical Research Communications·D Jourd'heuilM B Grisham
Feb 15, 2001·Nature Cell Biology·S R JaffreyS H Snyder
Jan 18, 2002·The Journal of Biological Chemistry·Andrew J GowJonathan S Stamler
Oct 5, 2002·Circulation Research·Thomas R ShannonDonald M Bers
Nov 6, 2002·Biological Research·Cecilia HidalgoPaulina Donoso
Nov 9, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Paul M L JanssenEduardo Marbán
Aug 16, 2003·The Journal of Biological Chemistry·Paula AracenaCecilia Hidalgo
Dec 25, 2004·Proceedings of the National Academy of Sciences of the United States of America·Yi Yang, Joseph Loscalzo
Feb 3, 2005·Nature Reviews. Molecular Cell Biology·Douglas T HessJonathan S Stamler
Mar 15, 2005·The Journal of Clinical Investigation·Frank J Giordano
Mar 15, 2005·The Journal of Clinical Investigation·Joshua M Hare, Jonathan S Stamler
Oct 26, 2005·Journal of Molecular and Cellular Cardiology·Gina SánchezPaulina Donoso
Dec 17, 2005·Circulation Research·Khalid M MinhasJoshua M Hare
Jan 13, 2006·Proceedings of the National Academy of Sciences of the United States of America·Xander H T WehrensAndrew R Marks
Mar 18, 2006·Arteriosclerosis, Thrombosis, and Vascular Biology·Diane E Handy, Joseph Loscalzo
Oct 4, 2006·Circulation·Jeffrey M Zimmet, Joshua M Hare
Nov 23, 2006·Physiology·Donald M Bers
Nov 21, 2007·Nitric Oxide : Biology and Chemistry·Daniel R GonzálezMauricio P Boric
Dec 14, 2007·Proceedings of the National Academy of Sciences of the United States of America·Daniel R GonzalezJoshua M Hare
Feb 13, 2008·Proceedings of the National Academy of Sciences of the United States of America·Andrew M BellingerAndrew R Marks
Mar 21, 2008·American Journal of Physiology. Cell Physiology·David R L ScrivenEdwin D W Moore
Feb 10, 2009·Nature Medicine·Andrew M BellingerAndrew R Marks
Mar 28, 2009·Proceedings of the National Academy of Sciences of the United States of America·Brian LimaHoward A Rockman

❮ Previous
Next ❯

Citations

Jun 7, 2011·Acta Pharmacologica Sinica·Mark D McCauley, Xander H T Wehrens
Sep 8, 2011·Proceedings of the National Academy of Sciences of the United States of America·Qi-An SunJonathan S Stamler
Mar 1, 2012·Proceedings of the National Academy of Sciences of the United States of America·Farideh BeigiJoshua M Hare
Oct 17, 2012·Proceedings of the National Academy of Sciences of the United States of America·Michael J CutlerKenneth R Laurita
May 15, 2013·Proceedings of the National Academy of Sciences of the United States of America·Jennifer J SmithAngela F Dulhunty
Aug 18, 2012·Antioxidants & Redox Signaling·Nitin T Aggarwal, Jonathan C Makielski
Jul 10, 2012·Antioxidants & Redox Signaling·Bradley A MaronJoseph Loscalzo
Nov 20, 2012·Antioxidants & Redox Signaling·Alicia M EvangelistaElizabeth Murphy
Jan 10, 2012·Cardiovascular Research·Boris ManouryJean-Luc Balligand
Feb 15, 2013·Cardiovascular Research·Andriy E BelevychSandor Györke
Mar 5, 2013·Cardiovascular Research·Huiliang ZhangHeping Cheng
Sep 14, 2011·Oxidative Medicine and Cellular Longevity·Igor Afanas'ev
Jan 2, 2014·Pharmacology & Therapeutics·Lifei TangMark T Ziolo
Dec 21, 2013·Journal of Molecular and Cellular Cardiology·M B NollyI L Ennis
Sep 14, 2014·Heart Failure Clinics·Robert T ColeJaved Butler
Sep 24, 2013·Antioxidants & Redox Signaling·Paula Nunes, Nicolas Demaurex
May 8, 2014·Antioxidants & Redox Signaling·Mark T Ziolo, Steven R Houser
Feb 22, 2011·Circulation Research·Giulio AgnettiJennifer E Van Eyk
Jan 15, 2013·American Journal of Physiology. Heart and Circulatory Physiology·Nathan D Roe, Jun Ren
May 16, 2012·Heart Failure Reviews·Marc Kaufman, Maya Guglin
Mar 10, 2015·Circulation Journal : Official Journal of the Japanese Circulation Society·Euy-Myoung Jeong, Samuel C Dudley
Mar 18, 2015·Pharmacology & Therapeutics·Lucy MurfittAshraf Kitmitto
Sep 20, 2011·Free Radical Biology & Medicine·James D GladdenLouis J Dell'Italia
May 4, 2011·Biochimica Et Biophysica Acta·Ivonne Hernandez Schulman, Joshua M Hare
Feb 15, 2011·Trends in Pharmacological Sciences·Michael J CutlerDavid S Rosenbaum
Dec 18, 2014·Biophysical Journal·Natalia ShirokovaErnst Niggli
Mar 1, 2016·Nitric Oxide : Biology and Chemistry·Xiaoyu LiuYingjie Chen
Mar 19, 2014·Journal of Molecular and Cellular Cardiology·Jillian N SimonRicardo Carnicer
Jun 19, 2013·Biochimica Et Biophysica Acta·Sameer AtherXander H T Wehrens
Sep 11, 2012·Biochimica Et Biophysica Acta·Ernst NiggliNatalia Shirokova
Mar 2, 2013·Journal of the American College of Cardiology·Vasileios KarantalisJoshua M Hare
Jan 18, 2011·Free Radical Biology & Medicine·Celio X C SantosAjay M Shah
Jun 3, 2014·Biochimica Et Biophysica Acta·Maria Giulia BattelliLetizia Polito
Dec 10, 2013·Journal of the American College of Cardiology·Masafumi Yano, Shinichi Okuda
Jan 15, 2014·Journal of Molecular and Cellular Cardiology·Paulina DonosoRicardo Bull
Sep 13, 2011·Journal of Molecular and Cellular Cardiology·Elizabeth MurphyCharles Steenbergen
Oct 21, 2016·Cardiovascular Drugs and Therapy·Catarina FranciscoAdelino Leite-Moreira
Feb 25, 2014·The Diabetes Educator·Melissa L WallsMichelle D Johnson-Jennings

❮ Previous
Next ❯

Related Concepts

Related Feeds

ASBMB Publications

The American Society for Biochemistry and Molecular Biology (ASBMB) includes the Journal of Biological Chemistry, Molecular & Cellular Proteomics, and the Journal of Lipid Research. Discover the latest research from ASBMB here.

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.