Impaired Secretion of TNF-α by Monocytes Stimulated With EBV Peptides Associates With Infectious Complications After Kidney Transplantation

Transplantation
Patrice VallinSacha A De Serres

Abstract

The successful development of immunosuppressive agents has paradoxically led to an era in which adverse effects of immunosuppression, such as infections and cancer, are now a major concern in solid organ recipients. Nevertheless, the main focus of immune monitoring research remains the identification of rejection. There is currently no clinical tool to assess the net state of immunosuppression or to identify patients at increased risk of infectious complications. We report a prospective, longitudinal study in which we conducted detailed phenotyping of over 300 peripheral blood mononuclear cell samples from 45 kidney recipients during the first 24 months posttransplant. Patients were classified as cases or controls according to the following events: an opportunistic infection, recurring bacterial infections, or de novo neoplasia. Using a training cohort, an exploratory analysis revealed that the TNFα response to synthetic Epstein-Barr virus peptides by CD14CD16 monocytes was lower in cases. A classifier rule based on 2 or greater consecutive values below a threshold of 73% of TNFα-positive cells provided a sensitivity and specificity of 83%. In the validation cohort, the assay exhibited a sensitivity of 90% and a specificity of ...Continue Reading

References

Jan 5, 2000·Kidney International·A O OjoF K Port
Feb 14, 2004·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Herwig-Ulf Meier-KriescheBruce Kaplan
Feb 14, 2004·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Vikas R DharnidharkaWilliam E Harmon
Dec 24, 2004·The New England Journal of Medicine·Philip F Halloran
Jan 30, 2007·Journal of Clinical Immunology·Jana CinovaLudmila Tucková
Dec 21, 2007·The New England Journal of Medicine·Henrik EkbergUNKNOWN ELITE-Symphony Study
Dec 21, 2007·The New England Journal of Medicine·Jay A Fishman
Feb 29, 2008·Annual Review of Immunology·Natalya V SerbinaEric G Pamer
Mar 20, 2008·Clinical Journal of the American Society of Nephrology : CJASN·Aaron Dall, Sundaram Hariharan
Aug 15, 2008·Clinical Journal of the American Society of Nephrology : CJASN·Sawako KatoBengt Lindholm
Oct 10, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Claudia SommererMartin Zeier
Jan 10, 2009·Annual Review of Immunology·Cedric AuffrayFrederic Geissmann
May 16, 2009·International Journal of Cancer. Journal International Du Cancer·Claire M Vajdic, Marina T van Leeuwen
Sep 3, 2009·Current Opinion in Nephrology and Hypertension·Nina BabelHans-Dieter Volk
Dec 17, 2009·Therapeutic Drug Monitoring·Huub H van RossumJohannes van Pelt
Jan 6, 2010·Transplantation·Helen PilmoreSteven J Chadban
Jan 30, 2010·Journal of the American Society of Nephrology : JASN·Robert P CarrollKathryn J Wood
Jul 1, 2011·Clinical Pharmacology and Therapeutics·K BuddeP Glander
Mar 7, 2012·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·P Hirt-MinkowskiS Schaub
Jun 29, 2012·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Emilio RodrigoManuel Arias
Oct 3, 2012·Transplantation Proceedings·H Sanders-PinheiroM G Bastos
May 4, 2013·Transplantation Reviews·Timm HeinbokelStefan G Tullius
Jun 20, 2013·Transplantation·Claire Borni-DuvalBruno Moulin
Aug 24, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·D E HricikUNKNOWN CTOT-01 consortium
Oct 3, 2013·Cold Spring Harbor Perspectives in Medicine·Jay A Fishman
Nov 8, 2013·The New England Journal of Medicine·Manikkam Suthanthiran, Thangamani Muthukumar
Nov 8, 2013·The New England Journal of Medicine·Stefan Schaub, Patricia Hirt-Minkowski
Nov 8, 2013·The New England Journal of Medicine·Pierre GalichonEric Rondeau
Jul 19, 2014·Nature Reviews. Immunology·Martin GuilliamsSimon Yona
Dec 17, 2014·Clinical & Translational Immunology·Mario Fernández-RuizAtul Humar
Mar 27, 2015·Science Translational Medicine·Jeffrey A Bluestone, Qizhi Tang
Mar 27, 2015·Science Translational Medicine·Cameron McDonald-HymanBruce R Blazar
Oct 3, 2015·Clinical Journal of the American Society of Nephrology : CJASN·Pietro E CippàCorrado Bernasconi
Mar 16, 2016·Therapeutic Drug Monitoring·Mercè BrunetMichael Oellerich
Jan 25, 2017·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J A Fishman

❮ Previous
Next ❯

Citations

Feb 21, 2018·Transplantation·Daniel Zecher
Feb 23, 2020·Expert Review of Anti-infective Therapy·Mario Fernández-RuizJosé María Aguado
Nov 15, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·François Bouchard-BoivinSacha A De Serres
Feb 25, 2021·Transplantation·Xunrong Luo
May 20, 2021·Transplantation·Xunrong Luo

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.